VEXIN_HUMAN
ID VEXIN_HUMAN Reviewed; 207 AA.
AC Q8TAG6; B2RDC3; B4DFU4; C9J814; C9JCS3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Vexin {ECO:0000250|UniProtKB:Q8BG31};
GN Name=VXN {ECO:0000312|HGNC:HGNC:28498};
GN Synonyms=C8orf46 {ECO:0000312|HGNC:HGNC:28498};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Amygdala, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for neurogenesis in the neural plate and retina.
CC Strongly cooperates with neural bHLH factors to promote neurogenesis.
CC {ECO:0000250|UniProtKB:Q8BG31}.
CC -!- INTERACTION:
CC Q8TAG6; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-12071548, EBI-12011224;
CC Q8TAG6; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-12071548, EBI-739624;
CC Q8TAG6; Q14192: FHL2; NbExp=3; IntAct=EBI-12071548, EBI-701903;
CC Q8TAG6; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12071548, EBI-741158;
CC Q8TAG6; P36508: ZNF76; NbExp=3; IntAct=EBI-12071548, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BG31}.
CC Nucleus {ECO:0000250|UniProtKB:Q8BG31}. Note=Nuclear localization is
CC essential for its function in neurogenesis.
CC {ECO:0000250|UniProtKB:Q8BG31}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TAG6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAG6-2; Sequence=VSP_038986;
CC -!- SIMILARITY: Belongs to the vexin family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28400.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG37870.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK294261; BAG57555.1; -; mRNA.
DR EMBL; AK315486; BAG37870.1; ALT_INIT; mRNA.
DR EMBL; AC009879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028400; AAH28400.1; ALT_INIT; mRNA.
DR CCDS; CCDS6191.2; -. [Q8TAG6-1]
DR RefSeq; NP_689978.2; NM_152765.3. [Q8TAG6-1]
DR AlphaFoldDB; Q8TAG6; -.
DR BioGRID; 129048; 16.
DR IntAct; Q8TAG6; 5.
DR STRING; 9606.ENSP00000302260; -.
DR iPTMnet; Q8TAG6; -.
DR PhosphoSitePlus; Q8TAG6; -.
DR BioMuta; C8orf46; -.
DR MassIVE; Q8TAG6; -.
DR PaxDb; Q8TAG6; -.
DR PeptideAtlas; Q8TAG6; -.
DR PRIDE; Q8TAG6; -.
DR ProteomicsDB; 73881; -. [Q8TAG6-1]
DR ProteomicsDB; 73882; -. [Q8TAG6-2]
DR Antibodypedia; 65917; 14 antibodies from 9 providers.
DR DNASU; 254778; -.
DR Ensembl; ENST00000305454.8; ENSP00000302260.3; ENSG00000169085.13. [Q8TAG6-1]
DR Ensembl; ENST00000522977.5; ENSP00000430141.1; ENSG00000169085.13. [Q8TAG6-2]
DR GeneID; 254778; -.
DR KEGG; hsa:254778; -.
DR MANE-Select; ENST00000305454.8; ENSP00000302260.3; NM_152765.4; NP_689978.2.
DR UCSC; uc003xwg.4; human. [Q8TAG6-1]
DR CTD; 254778; -.
DR DisGeNET; 254778; -.
DR GeneCards; VXN; -.
DR HGNC; HGNC:28498; VXN.
DR HPA; ENSG00000169085; Tissue enriched (brain).
DR neXtProt; NX_Q8TAG6; -.
DR OpenTargets; ENSG00000169085; -.
DR PharmGKB; PA142672365; -.
DR VEuPathDB; HostDB:ENSG00000169085; -.
DR eggNOG; ENOG502S3CJ; Eukaryota.
DR GeneTree; ENSGT00390000010499; -.
DR HOGENOM; CLU_116780_0_0_1; -.
DR InParanoid; Q8TAG6; -.
DR OMA; DRWDTGD; -.
DR OrthoDB; 1228752at2759; -.
DR PhylomeDB; Q8TAG6; -.
DR TreeFam; TF336189; -.
DR PathwayCommons; Q8TAG6; -.
DR SignaLink; Q8TAG6; -.
DR BioGRID-ORCS; 254778; 23 hits in 1053 CRISPR screens.
DR ChiTaRS; C8orf46; human.
DR GenomeRNAi; 254778; -.
DR Pharos; Q8TAG6; Tdark.
DR PRO; PR:Q8TAG6; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8TAG6; protein.
DR Bgee; ENSG00000169085; Expressed in C1 segment of cervical spinal cord and 100 other tissues.
DR ExpressionAtlas; Q8TAG6; baseline and differential.
DR Genevisible; Q8TAG6; HS.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; ISS:UniProtKB.
DR InterPro; IPR040470; Vexin.
DR InterPro; IPR027900; Vexin_dom.
DR PANTHER; PTHR31520; PTHR31520; 1.
DR Pfam; PF15505; DUF4648; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Membrane; Neurogenesis; Nucleus;
KW Reference proteome.
FT CHAIN 1..207
FT /note="Vexin"
FT /id="PRO_0000271014"
FT REGION 56..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 94..207
FT /note="VGISEPKTSNLCGNRAYGKSLIPPVPRISVKTSASASLEATAMGTEKGAVLM
FT RGSRHLKKMTEEYPALPQGAEASLPLTGSASCGVPGILRKMWTRHKKKSEYVGATNSAF
FT EAD -> DTASAPDLSENFSLCLIGGDSHGHREGSCSDERIQTSQEDD (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_038986"
SQ SEQUENCE 207 AA; 22584 MW; D286DC197382B369 CRC64;
MMHQIYSCSD ENIEVFTTVI PSKVSSPARR RAKSSQHLLT KNVVIESDLY THQPLELLPH
RGDRRDPGDR RRFGRLQTAR PPTAHPAKAS ARPVGISEPK TSNLCGNRAY GKSLIPPVPR
ISVKTSASAS LEATAMGTEK GAVLMRGSRH LKKMTEEYPA LPQGAEASLP LTGSASCGVP
GILRKMWTRH KKKSEYVGAT NSAFEAD
