ID   VEXIN_MOUSE             Reviewed;         207 AA.
AC   Q8BG31;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Vexin {ECO:0000303|PubMed:29518376};
GN   Name=Vxn {ECO:0000303|PubMed:29518376};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain cortex;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29518376; DOI=10.1016/j.ydbio.2018.03.003;
RA   Moore K.B., Logan M.A., Aldiri I., Roberts J.M., Steele M., Vetter M.L.;
RT   "C8orf46 homolog encodes a novel protein Vexin that is required for
RT   neurogenesis in Xenopus laevis.";
RL   Dev. Biol. 437:27-40(2018).
CC   -!- FUNCTION: Required for neurogenesis in the neural plate and retina.
CC       Strongly cooperates with neural bHLH factors to promote neurogenesis
CC       (PubMed:29518376). {ECO:0000269|PubMed:29518376}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29518376}.
CC       Nucleus {ECO:0000269|PubMed:29518376}. Note=Nuclear localization is
CC       essential for its function in neurogenesis.
CC       {ECO:0000269|PubMed:29518376}.
CC   -!- SIMILARITY: Belongs to the vexin family. {ECO:0000305}.
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DR   EMBL; AK043576; BAC31586.1; -; mRNA.
DR   EMBL; AK043759; BAC31645.1; -; mRNA.
DR   EMBL; BC066997; AAH66997.1; -; mRNA.
DR   CCDS; CCDS14813.1; -.
DR   RefSeq; NP_848486.1; NM_178399.4.
DR   AlphaFoldDB; Q8BG31; -.
DR   STRING; 10090.ENSMUSP00000086041; -.
DR   PhosphoSitePlus; Q8BG31; -.
DR   PaxDb; Q8BG31; -.
DR   PRIDE; Q8BG31; -.
DR   Antibodypedia; 65917; 14 antibodies from 9 providers.
DR   Ensembl; ENSMUST00000088666; ENSMUSP00000086041; ENSMUSG00000067879.
DR   GeneID; 76982; -.
DR   KEGG; mmu:76982; -.
DR   UCSC; uc007agp.1; mouse.
DR   CTD; 254778; -.
DR   MGI; MGI:1924232; Vxn.
DR   VEuPathDB; HostDB:ENSMUSG00000067879; -.
DR   eggNOG; ENOG502S3CJ; Eukaryota.
DR   GeneTree; ENSGT00390000010499; -.
DR   HOGENOM; CLU_116780_0_0_1; -.
DR   InParanoid; Q8BG31; -.
DR   OMA; DRWDTGD; -.
DR   OrthoDB; 1228752at2759; -.
DR   PhylomeDB; Q8BG31; -.
DR   TreeFam; TF336189; -.
DR   BioGRID-ORCS; 76982; 4 hits in 69 CRISPR screens.
DR   ChiTaRS; Vxn; mouse.
DR   PRO; PR:Q8BG31; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q8BG31; protein.
DR   Bgee; ENSMUSG00000067879; Expressed in primary motor cortex and 78 other tissues.
DR   Genevisible; Q8BG31; MM.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0022008; P:neurogenesis; IMP:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; IMP:UniProtKB.
DR   InterPro; IPR040470; Vexin.
DR   InterPro; IPR027900; Vexin_dom.
DR   PANTHER; PTHR31520; PTHR31520; 1.
DR   Pfam; PF15505; DUF4648; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Neurogenesis; Nucleus; Reference proteome.
FT   CHAIN           1..207
FT                   /note="Vexin"
FT                   /id="PRO_0000271015"
FT   REGION          65..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   207 AA;  22491 MW;  CEAB7539D324CEAF CRC64;
     MHQIYSCSDE NIEVFTTVIP SKVSSSSRRR VKSSHHLLAK NVVIESDLYP PPRPLELLPQ
     RCERRDTGDR RWLQTGRLQT ARPPGAHPTK TPSRPVGISE PKTSNLCGNR AYGKSLIPPV
     ARISVKAPAG AEVAAKGSEH GAVLGRGSRH LKKIAEEYPA LPQGAEASLP LTGSTSCGVP
     GILRKMWTRH KKKSEYVGAT NSAFEAD