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VEXIN_PONAB
ID   VEXIN_PONAB             Reviewed;         207 AA.
AC   Q5R5R7; Q5R6C5; Q5R7X8;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 3.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Vexin {ECO:0000250|UniProtKB:Q8BG31};
GN   Name=VXN {ECO:0000250|UniProtKB:Q8BG31};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for neurogenesis in the neural plate and retina.
CC       Strongly cooperates with neural bHLH factors to promote neurogenesis.
CC       {ECO:0000250|UniProtKB:Q8BG31}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BG31}.
CC       Nucleus {ECO:0000250|UniProtKB:Q8BG31}. Note=Nuclear localization is
CC       essential for its function in neurogenesis.
CC       {ECO:0000250|UniProtKB:Q8BG31}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5R5R7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5R5R7-2; Sequence=VSP_022265;
CC   -!- SIMILARITY: Belongs to the vexin family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH92132.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CR859981; CAH92132.1; ALT_INIT; mRNA.
DR   EMBL; CR860566; CAH92691.1; -; mRNA.
DR   EMBL; CR860789; CAH92899.1; -; mRNA.
DR   RefSeq; NP_001126701.1; NM_001133229.1.
DR   RefSeq; NP_001128851.1; NM_001135379.1.
DR   AlphaFoldDB; Q5R5R7; -.
DR   STRING; 9601.ENSPPYP00000020908; -.
DR   Ensembl; ENSPPYT00000059219; ENSPPYP00000025649; ENSPPYG00000018639. [Q5R5R7-2]
DR   GeneID; 100189770; -.
DR   KEGG; pon:100189770; -.
DR   CTD; 254778; -.
DR   eggNOG; ENOG502S3CJ; Eukaryota.
DR   GeneTree; ENSGT00390000010499; -.
DR   OrthoDB; 1228752at2759; -.
DR   Proteomes; UP000001595; Chromosome 8.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; ISS:UniProtKB.
DR   InterPro; IPR040470; Vexin.
DR   InterPro; IPR027900; Vexin_dom.
DR   PANTHER; PTHR31520; PTHR31520; 1.
DR   Pfam; PF15505; DUF4648; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Membrane; Neurogenesis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..207
FT                   /note="Vexin"
FT                   /id="PRO_0000271016"
FT   REGION          55..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         42
FT                   /note="N -> NILSLLLEFTGITKDPETPWTRAPSAKLPPWGSVGLEARAEEWANRA
FT                   SPARQ (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_022265"
FT   CONFLICT        9
FT                   /note="S -> G (in Ref. 1; CAH92899)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        41
FT                   /note="K -> R (in Ref. 1; CAH92899)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        51
FT                   /note="T -> A (in Ref. 1; CAH92691/CAH92899)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        157
FT                   /note="E -> K (in Ref. 1; CAH92691)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        179
FT                   /note="V -> I (in Ref. 1; CAH92132)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   207 AA;  22485 MW;  D33DDCB97282B379 CRC64;
     MMHQIYSCSD ENIEVFTTVI PSKVSSPARR RAKSSQHLLT KNVVIESDLY THQPLELLPH
     RGDRRDPGDG RRFGRLQTAR PPTAHPAKAS ARPVGISEPK TSNLCGNRAY GKSLIPPVPR
     ISVKTSASAS LEATAMGTEK GAVLMRGSRH LKKMTEEYPA LPQGAEASLP LTGSASCGVP
     GILRKMWTRH KKKSEYVGAT NSAFEAD
 
 
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