VEXIN_PONAB
ID VEXIN_PONAB Reviewed; 207 AA.
AC Q5R5R7; Q5R6C5; Q5R7X8;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 3.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Vexin {ECO:0000250|UniProtKB:Q8BG31};
GN Name=VXN {ECO:0000250|UniProtKB:Q8BG31};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for neurogenesis in the neural plate and retina.
CC Strongly cooperates with neural bHLH factors to promote neurogenesis.
CC {ECO:0000250|UniProtKB:Q8BG31}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BG31}.
CC Nucleus {ECO:0000250|UniProtKB:Q8BG31}. Note=Nuclear localization is
CC essential for its function in neurogenesis.
CC {ECO:0000250|UniProtKB:Q8BG31}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5R5R7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5R5R7-2; Sequence=VSP_022265;
CC -!- SIMILARITY: Belongs to the vexin family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH92132.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CR859981; CAH92132.1; ALT_INIT; mRNA.
DR EMBL; CR860566; CAH92691.1; -; mRNA.
DR EMBL; CR860789; CAH92899.1; -; mRNA.
DR RefSeq; NP_001126701.1; NM_001133229.1.
DR RefSeq; NP_001128851.1; NM_001135379.1.
DR AlphaFoldDB; Q5R5R7; -.
DR STRING; 9601.ENSPPYP00000020908; -.
DR Ensembl; ENSPPYT00000059219; ENSPPYP00000025649; ENSPPYG00000018639. [Q5R5R7-2]
DR GeneID; 100189770; -.
DR KEGG; pon:100189770; -.
DR CTD; 254778; -.
DR eggNOG; ENOG502S3CJ; Eukaryota.
DR GeneTree; ENSGT00390000010499; -.
DR OrthoDB; 1228752at2759; -.
DR Proteomes; UP000001595; Chromosome 8.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; ISS:UniProtKB.
DR InterPro; IPR040470; Vexin.
DR InterPro; IPR027900; Vexin_dom.
DR PANTHER; PTHR31520; PTHR31520; 1.
DR Pfam; PF15505; DUF4648; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Membrane; Neurogenesis; Nucleus;
KW Reference proteome.
FT CHAIN 1..207
FT /note="Vexin"
FT /id="PRO_0000271016"
FT REGION 55..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 42
FT /note="N -> NILSLLLEFTGITKDPETPWTRAPSAKLPPWGSVGLEARAEEWANRA
FT SPARQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_022265"
FT CONFLICT 9
FT /note="S -> G (in Ref. 1; CAH92899)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="K -> R (in Ref. 1; CAH92899)"
FT /evidence="ECO:0000305"
FT CONFLICT 51
FT /note="T -> A (in Ref. 1; CAH92691/CAH92899)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="E -> K (in Ref. 1; CAH92691)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="V -> I (in Ref. 1; CAH92132)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 207 AA; 22485 MW; D33DDCB97282B379 CRC64;
MMHQIYSCSD ENIEVFTTVI PSKVSSPARR RAKSSQHLLT KNVVIESDLY THQPLELLPH
RGDRRDPGDG RRFGRLQTAR PPTAHPAKAS ARPVGISEPK TSNLCGNRAY GKSLIPPVPR
ISVKTSASAS LEATAMGTEK GAVLMRGSRH LKKMTEEYPA LPQGAEASLP LTGSASCGVP
GILRKMWTRH KKKSEYVGAT NSAFEAD