ID   VEXIN_XENLA             Reviewed;         190 AA.
AC   A0A1L8FZ84;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=Vexin {ECO:0000303|PubMed:29518376};
GN   Name=vxn {ECO:0000303|PubMed:29518376}; Synonyms=sbt1;
GN   ORFNames=XELAEV_18032081mg;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J;
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA   Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA   Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA   Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA   Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA   Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA   Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA   Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA   Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA   Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA   Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY,
RP   AND DEVELOPMENTAL STAGE.
RX   PubMed=29518376; DOI=10.1016/j.ydbio.2018.03.003;
RA   Moore K.B., Logan M.A., Aldiri I., Roberts J.M., Steele M., Vetter M.L.;
RT   "C8orf46 homolog encodes a novel protein Vexin that is required for
RT   neurogenesis in Xenopus laevis.";
RL   Dev. Biol. 437:27-40(2018).
CC   -!- FUNCTION: Required for neurogenesis in the neural plate and retina.
CC       Cooperates with cell cycle inhibitor cdknx/p27(xic1) to enhance
CC       neurogenesis and increase the levels of the neuronal determination
CC       factor neurog2/X-ngngr-1 (PubMed:29518376).
CC       {ECO:0000269|PubMed:29518376}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29518376}.
CC       Nucleus {ECO:0000269|PubMed:29518376}. Note=Nuclear localization is
CC       essential for its function in neurogenesis.
CC       {ECO:0000269|PubMed:29518376}.
CC   -!- TISSUE SPECIFICITY: Expressed in differentiating progenitors in the
CC       developing central nervous system (CNS) (PubMed:29518376).
CC       {ECO:0000269|PubMed:29518376}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during the course of nervous system
CC       (CNS) development, with expression in differentiating primary neurons
CC       at stage 15, in the neural tube and olfactory placodes at stage 19, and
CC       in the developing eye and other anterior neural structures by stage 27.
CC       Expressed in the optic vesicle at stage 25, and increases in the eye at
CC       later stages (PubMed:29518376). {ECO:0000269|PubMed:29518376}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes
CC       inhibition of primary neurogenesis (PubMed:29518376).
CC       {ECO:0000269|PubMed:29518376}.
CC   -!- SIMILARITY: Belongs to the vexin family. {ECO:0000305}.
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DR   EMBL; CM004476; OCT76877.1; -; Genomic_DNA.
DR   RefSeq; XP_018123539.1; XM_018268050.1.
DR   AlphaFoldDB; A0A1L8FZ84; -.
DR   GeneID; 108719277; -.
DR   KEGG; xla:108719277; -.
DR   CTD; 108719277; -.
DR   Xenbase; XB-GENE-12484897; vxn.L.
DR   OrthoDB; 1228752at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 108719277; Expressed in neurula embryo and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0022008; P:neurogenesis; IMP:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; IMP:UniProtKB.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Neurogenesis; Nucleus; Reference proteome.
FT   CHAIN           1..190
FT                   /note="Vexin"
FT                   /id="PRO_0000444117"
FT   REGION          88..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   190 AA;  21154 MW;  E54E75AF50DBCC1A CRC64;
     MIKLHRQSYK NLQNISTASP SRVCKSARGK TSTAQKSHVN KGALSCDVHP HQAQELVSQQ
     VELLHVLHRN DEMWRLAVQD TTKHIQSAEK KASRFSRRKQ TAPPKTKSLR TPPACSTDKQ
     NAPTVPASPS SYETLGCREQ RPENPKDEAT LPLTAHNIPK KAPSLLEKIG LKLKRTVEYI
     GASNCAFEDD