ID   VEZA_XENLA              Reviewed;         774 AA.
AC   Q6PCG6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Vezatin;
GN   Name=vezt;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a pivotal role in the establishment of adherens
CC       junctions and their maintenance in adult life. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with myosin VIIa and the cadherin-catenins complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, adherens junction. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vezatin family. {ECO:0000305}.
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DR   EMBL; BC059333; AAH59333.1; -; mRNA.
DR   RefSeq; NP_001083222.1; NM_001089753.1.
DR   AlphaFoldDB; Q6PCG6; -.
DR   DNASU; 398809; -.
DR   GeneID; 398809; -.
DR   KEGG; xla:398809; -.
DR   CTD; 398809; -.
DR   Xenbase; XB-GENE-1015459; vezt.L.
DR   OrthoDB; 1379096at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 398809; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002142; C:stereocilia ankle link complex; ISS:UniProtKB.
DR   GO; GO:0017022; F:myosin binding; IEA:InterPro.
DR   GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR   InterPro; IPR026859; Myosin-bd.
DR   InterPro; IPR026858; Vezatin.
DR   PANTHER; PTHR15989; PTHR15989; 1.
DR   Pfam; PF12632; Vezatin; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Coiled coil; Membrane; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..774
FT                   /note="Vezatin"
FT                   /id="PRO_0000349251"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          746..774
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          430..457
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        759..774
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  88334 MW;  83148767328C95AA CRC64;
     MTAEFDEEVV FENSPLFQYL QDLGHTDFEI CPLSKEEERL AENGQGKQDV HTTEKKSIIS
     RTVEFLKSWS PFLSKKKKDE KIHLLEIGFR LESLRTILQQ EVLIQEDVEL IELLDPGILS
     AGQTQNQQND HLPTLWSIAT PNIWETSILF VFLSAVAAFQ SWSISSSLIW GPSLILFAAF
     TVLKTLHTWR SARLRIILRK YCTQVEGTVS NSRAFTNLVR KALRLIQETE VISRGFTLVS
     AACPYGKAGQ HASQHLLGLR KAVYRTVRTN FRISRLATLY MLKHYPLNSE IDNVTNYICV
     VPLKDLGLGL CEEHVSEEDA HNLTDAFSLP ALKVLFQLWI GQSSEFFRRL ALLLSPENAS
     QGPSTSPEQL PHFIWSDVVQ DLPHTQAACM AELKRSYEFY RYFETQHQSG LERTAKRKEV
     GELNNLHGAV RSLQLHLKAL LNEVIVLEDE LDKLSSCKEM QAVTPEASLM LEEKLRIIQP
     HVQASNTCWE EALCQVERMV RKPTTKKDTG KYSCENLNYP VVSNVPPAMR IEDRDPVPEE
     QILEAYVEEA VTDQEFNSEE IYLFSPEERE RQKREREESR RVLQELKAVL GLKASEAERQ
     KWKQLLFSEH AVITPLLPEE PVGHFEPLLS IYPEEPHKNL GFYGEIPSEI NGTEHVKDAP
     IQVDHGNMNH EDEAKICPVS EEVEPASCKE EEDETPCPAP RTVLPPAIKE RLARIHQSSD
     LNFTSGLATQ VAARSLTFTF LQEQTFGDEW DDDDDNEDHD HDKERNNDSS QLEG