ID   VEZA_XENTR              Reviewed;         791 AA.
AC   Q28C41;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Vezatin;
GN   Name=vezt; ORFNames=TEgg004g23.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a pivotal role in the establishment of adherens
CC       junctions and their maintenance in adult life. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with myosin VIIa and the cadherin-catenins complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, adherens junction. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vezatin family. {ECO:0000305}.
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DR   EMBL; CR942466; CAJ81723.1; -; mRNA.
DR   EMBL; BC136189; AAI36190.1; -; mRNA.
DR   RefSeq; NP_001039208.1; NM_001045743.1.
DR   AlphaFoldDB; Q28C41; -.
DR   SMR; Q28C41; -.
DR   STRING; 8364.ENSXETP00000051413; -.
DR   PaxDb; Q28C41; -.
DR   Ensembl; ENSXETT00000051413; ENSXETP00000051413; ENSXETG00000023853.
DR   GeneID; 734067; -.
DR   KEGG; xtr:734067; -.
DR   CTD; 55591; -.
DR   Xenbase; XB-GENE-1015453; vezt.
DR   eggNOG; ENOG502QTQW; Eukaryota.
DR   InParanoid; Q28C41; -.
DR   OrthoDB; 1379096at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023853; Expressed in brain and 13 other tissues.
DR   ExpressionAtlas; Q28C41; differential.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0002142; C:stereocilia ankle link complex; ISS:UniProtKB.
DR   GO; GO:0017022; F:myosin binding; IEA:InterPro.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   InterPro; IPR026859; Myosin-bd.
DR   InterPro; IPR026858; Vezatin.
DR   PANTHER; PTHR15989; PTHR15989; 1.
DR   Pfam; PF12632; Vezatin; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Coiled coil; Membrane; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..791
FT                   /note="Vezatin"
FT                   /id="PRO_0000349252"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          752..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          435..464
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        752..767
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        768..791
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   791 AA;  90155 MW;  06A139409E6A038E CRC64;
     MTAEFDEEVV FENSPLFQYL QDLGQTDFEI CPLSKEEEHL AGNGHGEQDV HTTEKKSNIS
     RTVEFLKSWS PLFSKKKRDE KICLLENGFR LESLRTILQQ EVLIQEDVEL IELLDPGILS
     AGQTQNQQNG HLPTLWSIAT PNIWEMSVLF AFLSALAALQ SWSISSSLVW GPSLILFAAF
     TVLRALHTWR SATLRMILRK YCNQVEGTVL NSRAFTNLVR KALRLIQETE VISRGFTLLL
     DRVSAACPYG KAGQHASQHL LGLRKAVYRT VRTNFRISRL ATLYMLKHYP LNSEIDNVTN
     YICVVPLKDL GLGLCEEHVS EEEAHNLTDA FSLPALKVLF QLWIGQSSEF FRRLALLLSP
     ENAAQGHLAS PEQLPHLIWS DVVQDLPHTQ AACLAELKRS YEFYRYFETQ HQSGFERTAK
     RKKEVGELSN LHGAVRSLQL HLKALLNEVI ILEDELEKLS SCKEMQAMTQ EASLMLEEKL
     RIIQPHVQAS NTCWEEALCQ VGRMVRRPAA KKDIEKSSCE NLNFPVVSNM PPALRIEDRD
     PVPEEQILEA YVEEAVTDQE FNSEDIYLFS PEERERQKRE REESKRVLQE LKAVLGLKAS
     EAERQKWKQL LFSEHAVITP FLPEEPVGHF EPPDSVYPED PCKNLGFYGE FTSEINGTEH
     AKDTPNQGDL QMNMNHEDEA KICPLSEEAE PESGKDENES PCPVPRTVLP PAIKERLARI
     HQTSDLNFTS GLAAQVAARS LTFTFLQEQT FGDEWDDDDD DNDNDDDNYD QVKNVESHEK
     ERNNVSLQLE E