ID   VF113_ASFP4             Reviewed;        1133 AA.
AC   P0C9A5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Early transcription factor large subunit homolog {ECO:0000250|UniProtKB:Q89525};
DE            EC=3.6.4.13;
DE   AltName: Full=ATP-dependent helicase VETFS homolog {ECO:0000250|UniProtKB:Q89525};
GN   OrderedLocusNames=Pret-118;
OS   African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561443;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative initation factor. {ECO:0000250|UniProtKB:P04308}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000250|UniProtKB:P04308};
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:Q89525}. Note=Found
CC       in association with viral nucleoid. {ECO:0000250|UniProtKB:Q89525}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000000859; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Late protein; Nucleotide-binding;
KW   Transcription; Transcription regulation; Virion.
FT   CHAIN           1..1133
FT                   /note="Early transcription factor large subunit homolog"
FT                   /id="PRO_0000373109"
FT   DOMAIN          52..352
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          524..724
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           281..284
FT                   /note="DEAH box"
FT   BINDING         99..106
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   1133 AA;  129294 MW;  7B349FE58BF18C5B CRC64;
     MAYPELDAAD FLQQLARRKE FKSLISPPVD QKELIRDLRA HFVQIGGPGC EKGGRAFFPC
     DPYASPFPSI KGLQLHNAQL FVQNFQNPNT PYSRLLLNWQ TGTGKSIAAI AIARQFMNHY
     MNFIENAPWI FVVGFTRAII QTEMLRRPEL GFVSYKEVAE LHRLLHIAKQ SGSTTSVESR
     HLNGFVSTLK RRLTDRNRGG FFQFYGYKEF ASKLFNITSK GEEKNFDVLS LFHRSDEAED
     TLNENDISQF VQKISEAETN GLIRVNQKIM EQLRGGLLIA DEIHNVYNIQ ERNNYGIALQ
     YVLDAFPPHQ APRAVFMSAT PVTGSVMEYV DLLNLLVPRH ELPNGQPLQR QQLFDSSGHS
     VKWKKDALAL VERLSTGRVS FLLDTNTNFY PERIFAGKML SYKDEKLPYL HFIECPMSEY
     QLETLKQLGP DPKISSNAYS IYDMVFPNPK FSKQTEPKAY GLFNSTETPT ALSMASTDWL
     LENGVQIIEP SRRAPFNVSG SFLSLQPPTH ISGLAFYSGK YTQMMKDILS IIRQGRGKIL
     IYHNRVRMSG VLILQEILQS NGILNEVSSP VGTTRCSICA AIRDDHTHSD HQFIPVRFTI
     LHSEIEPAVR ERSLALFNAS SNLEGHQLRI LIGSKVIVEG LNFQAVRYEM IMSLPLDIPR
     LIQVFGRVVR KNSHMELPPS ERNVTIYLYV STTPDGGPEL AKYAQKLKEY ILIQEGDKAL
     RKHAIDGFTN QIKIDKPMLE SLPLSPSITP ANVGATVLNT FEAYGYGEQE VKTISNIIIS
     LFMARPVWTY SELWKAVSTP KLIQGITIDN KLFSEDNFAL ALISLCYSKN QCKELWIQNR
     LCTIMHVPAK PEHLYVAAVL NHKKEPVLDI ETYIRDFQPP TMHSIRITKY LEHSQTKEPF
     QVLYEKFQKD FQDEPMEQVL IHYPASFHYT MLEALIIDNL AGMGALVEVY KKFFIAFSKK
     DIQPFPDIFK IISHVPGDDN TLVGYATEDS VRLITSREDK TWHEIPLYML NINVKRKEND
     IVIGYMESKG KALKFKIRPP IQVLKKNEIT DIRMLNRGAV CETRGREEQQ KIANQLGISL
     NLTKISAIKL CLLIRNNLLQ KEMEARNQPN GMQDGIRWFY LFNDKMPSLV HTS