ID   VF151_ASFB7             Reviewed;         151 AA.
AC   Q65140;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Protein A151R;
DE            Short=pA151R;
GN   OrderedLocusNames=Ba71V-037; ORFNames=A151R;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11831707; DOI=10.1006/viro.1995.1149;
RA   Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C.,
RA   Rodriguez J.F., Vinuela E.;
RT   "Analysis of the complete nucleotide sequence of African swine fever
RT   virus.";
RL   Virology 208:249-278(1995).
RN   [2]
RP   INTERACTION WITH B119L AND E248R.
RX   PubMed=16537584; DOI=10.1128/jvi.80.7.3157-3166.2006;
RA   Rodriguez I., Redrejo-Rodriguez M., Rodriguez J.M., Alejo A., Salas J.,
RA   Salas M.L.;
RT   "African swine fever virus pB119L protein is a flavin adenine dinucleotide-
RT   linked sulfhydryl oxidase.";
RL   J. Virol. 80:3157-3166(2006).
RN   [3]
RP   INDUCTION.
RX   PubMed=32075923; DOI=10.1128/jvi.00119-20;
RA   Cackett G., Matelska D., Sykora M., Portugal R., Malecki M., Baehler J.,
RA   Dixon L., Werner F.;
RT   "The African Swine Fever Virus Transcriptome.";
RL   J. Virol. 94:0-0(2020).
RN   [4]
RP   COFACTOR, AND SUBUNIT.
RC   STRAIN=Georgia 2007/1;
RX   PubMed=32828542; DOI=10.1016/j.bbrc.2020.08.011;
RA   Huang J.W., Niu D., Liu K., Wang Q., Ma L., Chen C.C., Zhang L., Liu W.,
RA   Zhou S., Min J., Wu S., Yang Y., Guo R.T.;
RT   "Structure basis of non-structural protein pA151R from African Swine Fever
RT   Virus.";
RL   Biochem. Biophys. Res. Commun. 532:108-113(2020).
CC   -!- FUNCTION: May participate in a redox cascade for the formation of
CC       disulfide bonds in viral proteins. {ECO:0000269|PubMed:32828542}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000269|PubMed:32828542};
CC       Note=Binds 1 Zn(2+) ion. {ECO:0000269|PubMed:32828542};
CC   -!- SUBUNIT: Monomer (PubMed:32828542). Homodimer (PubMed:32828542).
CC       Interacts with protein B119L (PubMed:16537584). Interacts with membrane
CC       protein E248R (PubMed:16537584). {ECO:0000269|PubMed:16537584,
CC       ECO:0000269|PubMed:32828542}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:32075923}.
CC   -!- SIMILARITY: Belongs to the asfivirus A151R family. {ECO:0000305}.
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DR   EMBL; U18466; AAA65267.1; -; Genomic_DNA.
DR   RefSeq; NP_042731.1; NC_001659.2.
DR   SMR; Q65140; -.
DR   GeneID; 22220419; -.
DR   KEGG; vg:22220419; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Early protein; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..151
FT                   /note="Protein A151R"
FT                   /id="PRO_0000373529"
FT   MOTIF           131..135
FT                   /note="Thioredoxin WCTKC motif"
FT                   /evidence="ECO:0000269|PubMed:32828542"
FT   BINDING         102
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000269|PubMed:32828542"
FT   BINDING         109
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000269|PubMed:32828542"
FT   BINDING         132
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000269|PubMed:32828542"
FT   BINDING         135
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000269|PubMed:32828542"
SQ   SEQUENCE   151 AA;  17623 MW;  FDFA986D06C356DD CRC64;
     MMALLHKEKL IECIENEVLS GGTVLLLVKN IVVSEISYID NSYKYFTFNA NHDLKSKEDL
     KGATSNNIAK MIYNWIIKNP QNNKIWSGEP RTQIYFENDL YHTNYNHECI KDFWDVSTSV
     GPCIFNDRSI WCTKCTSFYP FTNIMSPNIF Q