ID   VF169_ASFB7             Reviewed;         169 AA.
AC   Q65166;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 60.
DE   RecName: Full=Transmembrane protein B169L;
DE            Short=pB169L;
GN   OrderedLocusNames=Ba71V-076; ORFNames=B169L;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11831707; DOI=10.1006/viro.1995.1149;
RA   Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C.,
RA   Rodriguez J.F., Vinuela E.;
RT   "Analysis of the complete nucleotide sequence of African swine fever
RT   virus.";
RL   Virology 208:249-278(1995).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=30185597; DOI=10.1128/jvi.01293-18;
RA   Alejo A., Matamoros T., Guerra M., Andres G.;
RT   "A Proteomic Atlas of the African Swine Fever Virus Particle.";
RL   J. Virol. 92:0-0(2018).
RN   [3]
RP   ALTERNATIVE INITIATION.
RX   PubMed=32075923; DOI=10.1128/jvi.00119-20;
RA   Cackett G., Matelska D., Sykora M., Portugal R., Malecki M., Baehler J.,
RA   Dixon L., Werner F.;
RT   "The African Swine Fever Virus Transcriptome.";
RL   J. Virol. 94:0-0(2020).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Virion {ECO:0000269|PubMed:30185597}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q65166-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q65166-2; Sequence=VSP_061333;
CC   -!- INDUCTION: [Isoform 1]: Expressed in the late phase of the viral
CC       replicative cycle. {ECO:0000269|PubMed:32075923}.
CC   -!- INDUCTION: [Isoform 2]: Expressed in the early phase of the viral
CC       replicative cycle. {ECO:0000269|PubMed:32075923}.
CC   -!- SIMILARITY: Belongs to the asfivirus B169L family. {ECO:0000305}.
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DR   EMBL; U18466; AAA65306.1; -; Genomic_DNA.
DR   RefSeq; NP_042770.1; NC_001659.2.
DR   GeneID; 22220306; -.
DR   KEGG; vg:22220306; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Alternative initiation; Early protein; Glycoprotein; Host membrane;
KW   Late protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..169
FT                   /note="Transmembrane protein B169L"
FT                   /id="PRO_0000373548"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          107..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..91
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000269|PubMed:32075923"
FT                   /id="VSP_061333"
SQ   SEQUENCE   169 AA;  18688 MW;  30FD6743B3675697 CRC64;
     MNVDFIAGIN NLGEKIYTCE PFKTSFQNPF IVALIITAVV LVVFFAICNP PVDKKRKTKT
     AIYVYICIVA LLFLHYYVLN HQLNDIYNKS NMDVIVSSIH DKYKGGDEII PPISPPSVSN
     ELEEDQPKKI PAGPKPAGPK PADSKPASSA DSKPLVPLQE VIMPSQYNN