ID   VF193_IIV3              Reviewed;         206 AA.
AC   Q197D9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   02-JUN-2021, entry version 64.
DE   RecName: Full=Putative apoptosis inhibitor 021L;
GN   ORFNames=IIV3-021L;
OS   Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Chloriridovirus.
OX   NCBI_TaxID=345201;
OH   NCBI_TaxID=7163; Aedes vexans (Inland floodwater mosquito) (Culex vexans).
OH   NCBI_TaxID=42431; Culex territans.
OH   NCBI_TaxID=332058; Culiseta annulata.
OH   NCBI_TaxID=310513; Ochlerotatus sollicitans (eastern saltmarsh mosquito).
OH   NCBI_TaxID=329105; Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus).
OH   NCBI_TaxID=7183; Psorophora ferox.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16912294; DOI=10.1128/jvi.00464-06;
RA   Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A.,
RA   Kutish G.F., Rock D.L.;
RT   "Genome of invertebrate iridescent virus type 3 (mosquito iridescent
RT   virus).";
RL   J. Virol. 80:8439-8449(2006).
CC   -!- FUNCTION: Plays a role early in infection by preventing host cell
CC       apoptosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IIV-6 193R family. {ECO:0000305}.
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DR   EMBL; DQ643392; ABF82051.1; -; Genomic_DNA.
DR   RefSeq; YP_654593.1; NC_008187.1.
DR   SMR; Q197D9; -.
DR   GeneID; 4156270; -.
DR   KEGG; vg:4156270; -.
DR   Proteomes; UP000001358; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Early protein; Host-virus interaction;
KW   Inhibition of host caspases by virus; Metal-binding;
KW   Modulation of host cell apoptosis by virus; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..206
FT                   /note="Putative apoptosis inhibitor 021L"
FT                   /id="PRO_0000377904"
FT   ZN_FING         157..195
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          95..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  23536 MW;  0E37830816C3729A CRC64;
     MEESILRMHD KTTLKNMAFN RGLSRRGHNG RNASRMRKQD FIDFIMVQNH RDQSAVLGSD
     FLGDDMIRIF QEFIMDETFT FNPFIHLMGT IKNSTSKSPV SNQPSPEEDE PIPDLTLKPL
     EPCTKCECTT CMKNSIKQEE NLKVHQNILN LESKIMCVVC QANVRNVVFV PCNHLATCIS
     CSANPLMPKK CPMCRKGCKT TIKIFF