VF193_IIV6
ID VF193_IIV6 Reviewed; 208 AA.
AC P47732; O55770;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Apoptosis inhibitor 193R;
GN ORFNames=IIV6-193R;
OS Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Iridoviridae; Betairidovirinae; Iridovirus.
OX NCBI_TaxID=176652;
OH NCBI_TaxID=6997; Acheta domesticus (House cricket).
OH NCBI_TaxID=168631; Chilo suppressalis (Asiatic rice borer moth).
OH NCBI_TaxID=6999; Gryllus bimaculatus (Two-spotted cricket).
OH NCBI_TaxID=58607; Gryllus campestris.
OH NCBI_TaxID=7108; Spodoptera frugiperda (Fall armyworm).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11448171; DOI=10.1006/viro.2001.0963;
RA Jakob N.J., Mueller K., Bahr U., Darai G.;
RT "Analysis of the first complete DNA sequence of an invertebrate iridovirus:
RT coding strategy of the genome of Chilo iridescent virus.";
RL Virology 286:182-196(2001).
RN [2]
RP GENOME REANNOTATION.
RX PubMed=17239238; DOI=10.1186/1743-422x-4-11;
RA Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.;
RT "Comparative genomic analysis of the family Iridoviridae: re-annotating and
RT defining the core set of iridovirus genes.";
RL Virol. J. 4:11-11(2007).
RN [3]
RP FUNCTION.
RX PubMed=18420249; DOI=10.1016/j.virol.2008.03.009;
RA Ince I.A., Westenberg M., Vlak J.M., Demirbag Z., Nalcacioglu R.,
RA van Oers M.M.;
RT "Open reading frame 193R of Chilo iridescent virus encodes a functional
RT inhibitor of apoptosis (IAP).";
RL Virology 376:124-131(2008).
CC -!- FUNCTION: Plays a role early in infection by preventing host cell
CC apoptosis. {ECO:0000269|PubMed:18420249}.
CC -!- SIMILARITY: Belongs to the IIV-6 193R family. {ECO:0000305}.
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DR EMBL; AF303741; AAB94481.1; -; Genomic_DNA.
DR PIR; T03183; T03183.
DR RefSeq; NP_149656.1; NC_003038.1.
DR SMR; P47732; -.
DR GeneID; 1733224; -.
DR KEGG; vg:1733224; -.
DR Proteomes; UP000001359; Genome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd00022; BIR; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00653; BIR; 1.
DR SMART; SM00238; BIR; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Apoptosis; Early protein; Host-virus interaction;
KW Inhibition of host caspases by virus; Metal-binding;
KW Modulation of host cell apoptosis by virus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..208
FT /note="Apoptosis inhibitor 193R"
FT /id="PRO_0000122384"
FT REPEAT 37..108
FT /note="BIR"
FT REPEAT 134..139
FT /note="1"
FT REPEAT 140..145
FT /note="2"
FT REPEAT 146..151
FT /note="3"
FT ZN_FING 163..197
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..151
FT /note="3 X 6 AA tandem repeats"
FT BINDING 74
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 77
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 94
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 105
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ SEQUENCE 208 AA; 24142 MW; 41A2E2FC18833390 CRC64;
MDTCGIYNSD NEEFSQENDG ENDGGDKIIK NLPFASYDER LNSFQNWPIQ LLPSKEQLSR
AGFIYLNIGD QVQCFYCDLK LKEWKRSDNP FEEHKKHTQD LKINCLFVKS IEFDNFVKNH
SESCFQNPIT NNINQDLDHN QDLDHNQDLD QNSTTSDCDV LTCKICFTNK ITKVLIPCGH
SSCYECVFKL QTCPICKNNF IKINNLFI