ID   VF224_IIV3              Reviewed;         491 AA.
AC   Q197D6;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Probable cysteine proteinase 024R;
DE            EC=3.4.-.-;
GN   ORFNames=IIV3-024R;
OS   Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Chloriridovirus.
OX   NCBI_TaxID=345201;
OH   NCBI_TaxID=7163; Aedes vexans (Inland floodwater mosquito) (Culex vexans).
OH   NCBI_TaxID=42431; Culex territans.
OH   NCBI_TaxID=332058; Culiseta annulata.
OH   NCBI_TaxID=310513; Ochlerotatus sollicitans (eastern saltmarsh mosquito).
OH   NCBI_TaxID=329105; Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus).
OH   NCBI_TaxID=7183; Psorophora ferox.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16912294; DOI=10.1128/jvi.00464-06;
RA   Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A.,
RA   Kutish G.F., Rock D.L.;
RT   "Genome of invertebrate iridescent virus type 3 (mosquito iridescent
RT   virus).";
RL   J. Virol. 80:8439-8449(2006).
CC   -!- FUNCTION: Probable cysteine protease.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089}.
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DR   EMBL; DQ643392; ABF82054.1; -; Genomic_DNA.
DR   RefSeq; YP_654596.1; NC_008187.1.
DR   GeneID; 4156274; -.
DR   KEGG; vg:4156274; -.
DR   Proteomes; UP000001358; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Membrane; Protease; Reference proteome; Thiol protease;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..491
FT                   /note="Probable cysteine proteinase 024R"
FT                   /id="PRO_0000376963"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        132
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        325
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        355
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   491 AA;  55145 MW;  6D6C8EE17F01D7D9 CRC64;
     MTLEWNIDDK FHLFFRKKRS VYIVGGVHHD EDEVDPKVVA QSGLQGDDGV VRLPPLNTLV
     NFLGHVSPYM HADYAFLHRE WEYNRTASFA DDLVNLPSVY DWRYVYPRDD EETKRKKRYI
     MPPDNQYLCG SCWAVSTASA IGDAYVVAGL VDWRPDISPA WALTCYPQGQ CEGGSPALLL
     KEISQGNGIV SNHCLDYSFC ASNPRCNGAA ANHFGAENLS ELVPKSCGCY VGDSMHYRYT
     VDPLIRTLAI GVGTVTEENI QSTIKRHILT HGPVLAGYFV LKNFTSGYFT RINGGVYFDR
     GNYIPGQALV FNDHYCSGDS YRGSHAVAII GWGVARNVLY DTDKRGDVPY WYCRNSWRST
     WGGDDGYFKM AMYPWNRVAQ FEKLVTLRDR DNVPHRCGGI ITFTVSTKPV KVKMNQLNTT
     LLPFPLLRDR SWYGGDQEEY RPAIVPKLAP SDGPNKPPLP LPVYYSALDL ALLVLPALLI
     VIVVLIGKIP T