ID   VF224_IIV6              Reviewed;         449 AA.
AC   Q91FU7;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Probable cysteine proteinase 224L;
DE            EC=3.4.-.-;
GN   ORFNames=IIV6-224L;
OS   Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Iridovirus.
OX   NCBI_TaxID=176652;
OH   NCBI_TaxID=6997; Acheta domesticus (House cricket).
OH   NCBI_TaxID=168631; Chilo suppressalis (Asiatic rice borer moth).
OH   NCBI_TaxID=6999; Gryllus bimaculatus (Two-spotted cricket).
OH   NCBI_TaxID=58607; Gryllus campestris.
OH   NCBI_TaxID=7108; Spodoptera frugiperda (Fall armyworm).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11448171; DOI=10.1006/viro.2001.0963;
RA   Jakob N.J., Mueller K., Bahr U., Darai G.;
RT   "Analysis of the first complete DNA sequence of an invertebrate iridovirus:
RT   coding strategy of the genome of Chilo iridescent virus.";
RL   Virology 286:182-196(2001).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=17239238; DOI=10.1186/1743-422x-4-11;
RA   Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.;
RT   "Comparative genomic analysis of the family Iridoviridae: re-annotating and
RT   defining the core set of iridovirus genes.";
RL   Virol. J. 4:11-11(2007).
CC   -!- FUNCTION: Probable cysteine protease.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088}.
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DR   EMBL; AF303741; AAK82086.1; -; Genomic_DNA.
DR   RefSeq; NP_149687.1; NC_003038.1.
DR   MEROPS; C01.094; -.
DR   GeneID; 1733244; -.
DR   KEGG; vg:1733244; -.
DR   Proteomes; UP000001359; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Membrane; Protease; Reference proteome; Thiol protease;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..449
FT                   /note="Probable cysteine proteinase 224L"
FT                   /id="PRO_0000376964"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        99
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10088"
FT   ACT_SITE        292
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10088"
FT   ACT_SITE        322
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10088"
SQ   SEQUENCE   449 AA;  50789 MW;  3AB70304E178D232 CRC64;
     MKTKNRLLNS DIDFVNESIP YSRSDFNNML TKLSSNDYYQ LMVNTYIGTY GSAKFFGEST
     KTLPENFNWK TITEFDPPSI VSKKKLISEP ENQYLCGNCW AMSTVQTIGD RFVVAGLVNW
     VPDLSTTFAM LYYPQGQCDG GNSAKLMRQI HTGIGLASKH CIDYSWCSRN IECKTDNSLG
     HFVSENKSYL LPSKKGCYYN SKHYIYKIDS RPKIISGYGT LNTDNEVLNN QILLKQEILA
     NGPAVGGFLV FENFTSAFTK VNGGVYLENV SNYGSGKPVE FNPHINKYSG NHVVSILGWG
     VAKGIKISNT QFSDVPYWFC RNTWGKNWGD KGYFKIAMYP FNKKSQFLKL VSIVDHEGHT
     RRNSGVVICN VSETPILQSL PVIPSTEIPK SLDNSTNFYS QDENYEIKNN SQNEKGFPKG
     NRRRTTSSDT QIVFIFFLSV VILFIFIIL