ID   VF369_IIV3              Reviewed;         380 AA.
AC   Q196Y4;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Probable RAD2-like endonuclease 076L;
DE            EC=3.1.-.-;
GN   ORFNames=IIV3-076L;
OS   Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Chloriridovirus.
OX   NCBI_TaxID=345201;
OH   NCBI_TaxID=7163; Aedes vexans (Inland floodwater mosquito) (Culex vexans).
OH   NCBI_TaxID=42431; Culex territans.
OH   NCBI_TaxID=332058; Culiseta annulata.
OH   NCBI_TaxID=310513; Ochlerotatus sollicitans (eastern saltmarsh mosquito).
OH   NCBI_TaxID=329105; Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus).
OH   NCBI_TaxID=7183; Psorophora ferox.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16912294; DOI=10.1128/jvi.00464-06;
RA   Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A.,
RA   Kutish G.F., Rock D.L.;
RT   "Genome of invertebrate iridescent virus type 3 (mosquito iridescent
RT   virus).";
RL   J. Virol. 80:8439-8449(2006).
CC   -!- FUNCTION: Probable endonuclease. {ECO:0000305}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. {ECO:0000305}.
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DR   EMBL; DQ643392; ABF82106.1; -; Genomic_DNA.
DR   RefSeq; YP_654648.1; NC_008187.1.
DR   SMR; Q196Y4; -.
DR   GeneID; 4156287; -.
DR   KEGG; vg:4156287; -.
DR   Proteomes; UP000001358; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   InterPro; IPR006084; XPG/Rad2.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   PANTHER; PTHR11081; PTHR11081; 1.
DR   Pfam; PF00867; XPG_I; 1.
DR   Pfam; PF00752; XPG_N; 1.
DR   PRINTS; PR00853; XPGRADSUPER.
DR   SMART; SM00484; XPGI; 1.
DR   SMART; SM00485; XPGN; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Host nucleus; Hydrolase; Magnesium; Metal-binding; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..380
FT                   /note="Probable RAD2-like endonuclease 076L"
FT                   /id="PRO_0000377500"
FT   REGION          1..101
FT                   /note="N-domain"
FT                   /evidence="ECO:0000250"
FT   REGION          156..301
FT                   /note="I-domain"
FT                   /evidence="ECO:0000250"
FT   BINDING         32
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         73
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         191
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         193
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         212
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         214
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         281
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   380 AA;  43677 MW;  C6DADDF00F00BF8D CRC64;
     MGIKNLTQFL KKYKVYETID VAELKYSKIC IDTPMFLYKF VSQYPNSNEW LGCFVTLITW
     LRKWNIHPTF VFEGKAPPEK NQTQEARKES RQKIVSKTDA IEQDLRTYLK SGTITPLLLD
     TWQKIRSKST KSLLVKRPLN LIVKNFINVD EIRLEIDRRR KYEFSITFAH VNLLKELLDL
     MGVGYIQSKG EAEADCVSLW YNNAVDYIVS EDTDVLAYTF AGGAPGTSTP KKVPNTTDLK
     VITGFNVGES SATIISKQRV LSTLKMTAES FKDFCIMCGT DYNKNIFRVG VEKAYKYISD
     YKVIENVPLD TSVLDHHNVR KIFRVKKSIK YADKVQWSKY PSDNFVEVLN TFIWTHAGGT
     VDSDHVFRVL TDPALDIVFE