ID   VF859_ASFB7             Reviewed;         859 AA.
AC   Q65143;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Probable helicase A859L;
DE            EC=3.6.4.-;
GN   OrderedLocusNames=Ba71V-040; ORFNames=A859L;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11831707; DOI=10.1006/viro.1995.1149;
RA   Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C.,
RA   Rodriguez J.F., Vinuela E.;
RT   "Analysis of the complete nucleotide sequence of African swine fever
RT   virus.";
RL   Virology 208:249-278(1995).
CC   -!- SIMILARITY: Belongs to the asfivirus helicase A859L family.
CC       {ECO:0000305}.
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DR   EMBL; U18466; AAA65270.1; -; Genomic_DNA.
DR   RefSeq; NP_042734.1; NC_001659.2.
DR   SMR; Q65143; -.
DR   GeneID; 22220422; -.
DR   KEGG; vg:22220422; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR018306; Phage_T5_Orf172_DNA-bd.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF10544; T5orf172; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..859
FT                   /note="Probable helicase A859L"
FT                   /id="PRO_0000355211"
FT   DOMAIN          178..349
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          394..553
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           298..301
FT                   /note="DEAH box"
FT   BINDING         191..198
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   859 AA;  98576 MW;  BF6525E65EF515FA CRC64;
     MCAGFYVAVH PWLEAQSLHK VGHTGNLAAR LHDGSYTTCF TDEWKYCFTL ETSTKKDAQK
     IEAGVLYCAQ FFRVKNKELV CLLPEKIKQL AEDVANCLDI SYTLCDSPTY EMNDSTIVVE
     PSLPSDPLIS KEKLRHLVIT PVEDEEHFAD DVLFFSTDET RTAIEDRLYQ KEAANMGYQE
     LRRSGRAILQ MACRCGKTRV AYLILSNYLQ GKVLYLVPGL SLLRQTLEKL YQYGISLKNV
     LLVGSDQTRI VLNHDNIEMT TNPVFIAKRI REAPSLLVIA TYQSSTLLVD DFDLIISDEC
     HRICGEWETR PFTHVLLNFK KGHRLFLTAT PRYDTPLSMK NRELFGGVAF RYYLREGIEA
     GYVNDFELQM VAAPKLAHQP SNREETTKQI IVKQIIMALA YLKTNIPAPK MLVFTRDIKQ
     ARELYAELVD QGVYALIAHS TLPRQVILKT FTEFCSSKEP VILLNCRLFQ EGVEVPELNA
     VFFAAPRHSP RDIIQSICRP LNKQVQKPHA TIFLPLEVNT ENVCLDRFSS IIPFADALAS
     EDPRFYEHLL NPSEVAYPIN WIGAHGSVSE LLQLARHAIR YGTQGKIDRL TRSERLPWKA
     AFAELKRTVE ICCRYPKIND GFHFGGATLR FDTWYKWVIK SYLQYKNKEP SSLEPYQVSD
     LESLQDWTTR GVGGPYPWEE SMAFLETWLA QNKGELVAID IHQGGWIGLD ATPMERLSGV
     LTTVSQRDGR SYGKNKKLRP KKGFMIPPQQ AEDLDRIFGK HNLKWRKDRV NGFLKEDEHG
     NYTGEPTCIQ EAYRTFKEYV KTNPEYIEKY WPGYAKGKHK HQELPHIWES GLAPPRYKAF
     KDGNKQLIQR SPKKKDIKN