ID   VF859_ASFK5             Reviewed;         859 AA.
AC   P0C8H0;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Probable helicase A859L;
DE            EC=3.6.4.-;
GN   OrderedLocusNames=Ken-052;
OS   African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561445;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the asfivirus helicase A859L family.
CC       {ECO:0000305}.
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DR   EMBL; AY261360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C8H0; -.
DR   Proteomes; UP000000861; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR018306; Phage_T5_Orf172_DNA-bd.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF10544; T5orf172; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="Probable helicase A859L"
FT                   /id="PRO_0000355212"
FT   DOMAIN          178..349
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          394..553
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           298..301
FT                   /note="DEAH box"
FT   BINDING         191..198
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   859 AA;  98569 MW;  3FB07654F2F1D0D0 CRC64;
     MCAGFYVAVH PWLETQSLHK VGHTGNLAAR LHDGSYTTCF TDEWRYCFTL ETPTKKDAQK
     IEAGVLYCAQ FFRVKNKELL CLLPEKIKQL AEDVANCLNI SYTLCDAPTY EMNDSTIVVE
     PSSPSDPLIS KEKLRHLVIT PVEDEDRFAD DVLFFSTGET RTTIEDRLYQ REAANMGYQE
     LQRSGRAILQ MACRCGKTRV AYLILSNYLQ GKVLYLVPGL SLLRQTLEKL YLYGISLKNV
     MLVGSDQTRI VLNHDTIEMT TNPVIIVKRI QEASSLLVIA TYQSSTLLVD DFDLIISDEC
     HRICGEWETR PFTHVLLNFK KGHRLFLTAT PRYDTPLSMK NRELFGGVAF RYYLREGIEA
     GYVNDFELQM VAAPKLAHQL SNREETTKQI IVKQIIMALA YLKTNVRSPK MLVFTRDIKQ
     AKELYAELVD LGVYALIAHS TLPRQVILKT FTEFCSSKEP VILLNCRLFQ EGVEVPELNA
     VFFAAPRHSP RDIIQSICRP LNKQVQKPHA TIFLPLEVNT ENVCLDKFSS IIPFADALAS
     EDPRFYEHLL NPSEVAYPIN WIGAHGSVAE LLQLARHAIR YGTQGKIDRL TRSERLPWKA
     AFAELKRTVE ICCRYPKIND GFHFGGATLR FDTWYKWVIK SYLQYKNNEP SSLEPYQVLD
     LESLQDWTTR GVGGPYPWEE SMAFLETWLA QNKGELVAID IHQGGWIGLD ATPMERLSGV
     LTTVSQRDGR SYGKNRKLRP KKGFMIPPQQ AKDLDRIFGK HNLKWRKDRD NGFLKEDEHG
     NYTGEPTCIQ EAYQTFKEYV KTNPEYIEKY WPGYAKGKHK HQELPHIWES GLAPPRYKAF
     KDGNKRLIQR SPKKKDVKN