ID   VF859_ASFM2             Reviewed;         859 AA.
AC   P0C8H1;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Probable helicase A859L;
DE            EC=3.6.4.-;
GN   OrderedLocusNames=Mal-048;
OS   African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10500;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the asfivirus helicase A859L family.
CC       {ECO:0000305}.
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DR   EMBL; AY261361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C8H1; -.
DR   Proteomes; UP000000860; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR018306; Phage_T5_Orf172_DNA-bd.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF10544; T5orf172; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="Probable helicase A859L"
FT                   /id="PRO_0000355213"
FT   DOMAIN          178..349
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          394..553
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           298..301
FT                   /note="DEAH box"
FT   BINDING         191..198
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   859 AA;  98579 MW;  60818273F13E9C2B CRC64;
     MYAGFYVAVH PWLETQSLHK VGHTGNLAAR LHDGSYTTCF TDEWKYCFTL ETPTKKDAQK
     IEAGVLYCAQ FFRVKNKELL CLLPEKIKQL AEDVAKCLDI SYTLCDSPTY EMNDSTIVVE
     PSLPSDPLIS KEKLRHLVII PVEDEDHFAD DVLFFSTDET RTAIEDRLYQ KEAANMGYQE
     LQRSGRAILQ MACRCGKTRV AYLILSNYLQ GKVLYLVPGL SLLRQTLEKL YLYGISLKNV
     LLVGSDQTRI VLNHDNIEMT TNPVFIAKRI QEASSLLVIA TYQSSTLLVD DFDLIISDEC
     HRICGEWEIR PFTHVLLNFK KGHRLFLTAT PRYDTPLSMK NRDLFGGVAF RYYLREGIEA
     GYVNDFELQM VAAPKLAHQL SNREETTKQI IVKQIIMALA YLKTNITSPK MLVFTRDIKQ
     AKELYAELVD LGVYALIAHS TLPRQVILKT FTEFCSSKEP VILLNCRLFQ EGVEVPELNA
     VFFAAPRHSP RDIIQSICRP LNKQVQKPHA TIFLPLEVNT ENVCLDKFSS IIPFADALAS
     EDPRFYEHLL NPSEVAYPIN WIGAHGSVSE LLHLARHAIR YGTQGKIDRL TRSERLPWKA
     AFAELKRTVE ICCRYPKIND GFHFGGATLR FDTWYKWVIK SYLQYKNKEP SSLEPYQVSD
     LESLQDWTTR GVGGPYPWEE SMAFLETWLA QNKGELVAID IHQGGWIGLD ATPMERLSGV
     LTTVSQRDGR SYGKNKKLRP KKGFMIPPQQ AEDLDRIFGK HNLKWRKDRV NGFLKEDEHG
     NYTGEPTCIQ EAYRTFKEYV KTNPEYIEKY WPGYAKGKHK HQELPHIWES GLAPPRYKAF
     KDGNKQLIQR SPKKKDVKN