VF859_ASFP4
ID VF859_ASFP4 Reviewed; 859 AA.
AC P0C8H2;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 40.
DE RecName: Full=Probable helicase A859L;
DE EC=3.6.4.-;
GN OrderedLocusNames=Pret-052;
OS African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS (ASFV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Asfuvirales; Asfarviridae; Asfivirus.
OX NCBI_TaxID=561443;
OH NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kutish G.F., Rock D.L.;
RT "African swine fever virus genomes.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the asfivirus helicase A859L family.
CC {ECO:0000305}.
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DR EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; P0C8H2; -.
DR Proteomes; UP000000859; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018306; Phage_T5_Orf172_DNA-bd.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF10544; T5orf172; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding.
FT CHAIN 1..859
FT /note="Probable helicase A859L"
FT /id="PRO_0000355214"
FT DOMAIN 178..349
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 401..553
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT MOTIF 298..301
FT /note="DEAH box"
FT BINDING 191..198
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 859 AA; 98495 MW; FE55FD73B00A3673 CRC64;
MCAGFYVAVH PWLEAQSLHK VGHTGNLAAR LHDGSYTTCF TDEWKYCFTL ETSTKKDAQK
IEAGVLYCAQ FFRVKNKELV CLLPEKIKQL AEDVANCLDI SYTLCDSPAY EMNDSTIVVE
PSLPSDPLIS KEKLRHLVIT PVEDEEHFAD DVLFFSTDET RTAIEDRLYQ KEAANMGYQE
LRRSGRAILQ MACRCGKTRV AYLILSNYLQ GKVLYLVPGL SLLRQTLEKL YQYGISLKNV
LLVGSDQTRI VLNHDNIEMT TNPVFIAKRI REAPSLLVIA TYQSSTLLVD DFDLIISDEC
HRICGEWETR PFTHVLLNFK KGHRLFLTAT PRYDTPLSMK NRELFGGVAF RYYLREGIEA
GYVNDFELQM VAAPKLAHQP STKEETTKQI IVKQIIMALA HLKTNITAPK MLVFTRDIKQ
AKELYAELVD QGVYALIAHS TLPRQVILKT FTEFCSSKEP VILLNCRLFQ EGVEVPELNA
VFFAAPRHSP RDIIQSICRP LNKQVQKPHA TIFLPLEVNT ENVCLDRFSS IIPFADALAS
EDPRFYEHLL NPSEVAYPIN WIGAHGSVSE LLQLARHAIR YGTQGKIDRL TRSERLPWKA
AFAELKRTVE ICCRYPKIND GFHFGGATLR FDTWYKWVIK SYLQYKNKEP SSLEPYQVSD
LESLQDWTTR GVGGPYPWEE SMAFLETWLA QNKGELVAID IHQGGWIGLD ATPMERLSGV
LTTVSQRDGR SYGKNKKLRP KKGFMIPPQQ AQDLDRIFGK HNLKWRKDRV NGFLKEDEHG
NYTGEPTCIQ EAYRTFKEYV KTNPEYIEKY WPGYAKGKHK HQELPHIWEK GLAPPRYKAF
KDGNKQLIQR SPKKKDIKN