ID   VF859_ASFWA             Reviewed;         859 AA.
AC   P0C8H3;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Probable helicase A859L;
DE            EC=3.6.4.-;
GN   OrderedLocusNames=War-050;
OS   African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561444;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the asfivirus helicase A859L family.
CC       {ECO:0000305}.
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DR   EMBL; AY261366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C8H3; -.
DR   Proteomes; UP000000858; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR018306; Phage_T5_Orf172_DNA-bd.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF10544; T5orf172; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="Probable helicase A859L"
FT                   /id="PRO_0000355215"
FT   DOMAIN          178..349
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          401..553
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           298..301
FT                   /note="DEAH box"
FT   BINDING         191..198
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   859 AA;  98467 MW;  5E54EEE3B00A37B5 CRC64;
     MCAGFYVAVH PWLEAQSLHK VGHTGNLAAR LHDGSYTTCF TDEWKYCFTL ETSTKKDAQK
     IEAGVLYCAQ FFRVKNKELV CLLPEKIKQL AEDVANCLDI SYTLCDSPAY EMNDSTIVVE
     PSLPSDPLIS KEKLRHLVIT PVEDEEHFAD DVLFFSTDET RTAIEDRLYQ KEAANMGYQE
     LRRSGRAILQ MACRCGKTRV AYLILSNYLQ GKVLYLVPGL SLLRQTLEKL YQYGISLKNV
     LLVGSDQTRI VLNHDNIEMT TNPVFIAKRI REAPSLLVIA TYQSSTLLVD DFDLIISDEC
     HRICGEWETR PFTHVLLNFK KGHRLFLTAT PRYDTPLSMK NRELFGGVAF RYYLREGIEA
     GYVNDFELQM VAAPKLAHQP STKEETTKQI IVKQIIMALA HLKTNITAPK MLVFTRDIKQ
     AKELYAELVD QGVYALIAHS TLPRQVILKT FTEFCSSKEP VILLNCRLFQ EGVEVPELNA
     VFFAAPRHSP RDIIQSICRP LNKQVQKPHA TIFLPLEVNT ENVCLDRFSS IIPFADALAS
     EDPRFYEHLL NPSEVAYPIN WIGAHGSVSE LLQLARHAIR YGTQGKIDRL TRSERLPWKA
     AFAELKRTVE ICCRYPKIND GFHFGGATLR FDTWYKWVIK SYLQYKNKEP SSLEPYQVSD
     LESLQDWTTR GVGGPYPWEE SMAFLETWLA QNKGELVAID IHQGGWIGLD ATPMERLSGV
     LTTVSQRDGR SYGKNKKLRP KKGFMIPPQQ AQDLDRIFGK HNLKWRKDRV NGFLKEDEHG
     NYTGEPTCIQ EAYRTFKEYV KTNPDYIEKY WPGYAKGKHK HQELPHIWEK GLAPPRYKAF
     KDGNKQLIQR SPKKKDVKN