ID   VFE66_ASFP4             Reviewed;          45 AA.
AC   P0CAN1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 20.
DE   RecName: Full=host translation inhibitor E66L {ECO:0000305};
DE            Short=pE66L;
GN   OrderedLocusNames=Pret-148;
OS   African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561443;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits host protein translation, probably through the
CC       EIF2AK2/EIF2S1 signaling pathway (By similarity). Promotes cell
CC       retention in the G0/G1 phase (By similarity).
CC       {ECO:0000250|UniProtKB:Q65204}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q65204}.
CC   -!- SIMILARITY: Belongs to the asfivirus E66L family. {ECO:0000305}.
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DR   EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000000859; Genome.
DR   GO; GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Eukaryotic host translation shutoff by virus;
KW   G0/G1 host cell cycle checkpoint dysregulation by virus;
KW   Host endoplasmic reticulum; Host gene expression shutoff by virus;
KW   Host-virus interaction; Modulation of host cell cycle by virus.
FT   CHAIN           1..45
FT                   /note="host translation inhibitor E66L"
FT                   /id="PRO_0000373767"
SQ   SEQUENCE   45 AA;  5808 MW;  0B87500F84037EAC CRC64;
     MLKYIYMHLS HKYNHILFTY NMRIYLIKRN HMLFTHMFTT YAYIM