ID   VG15_BPPH8              Reviewed;         302 AA.
AC   P14815;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Replication protein 15;
GN   Name=15;
OS   Enterobacteria phage phi80 (Bacteriophage phi-80).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae.
OX   NCBI_TaxID=10713;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3172225; DOI=10.1016/0022-2836(88)90284-7;
RA   Ogawa T., Ogawa H., Tomizawa J.;
RT   "Organization of the early region of bacteriophage phi 80. Genes and
RT   proteins.";
RL   J. Mol. Biol. 202:537-550(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 109-186.
RX   PubMed=423961; DOI=10.1038/277621a0;
RA   Grosschedl R., Hobom G.;
RT   "DNA sequences and structural homologies of the replication origins of
RT   lambdoid bacteriophages.";
RL   Nature 277:621-627(1979).
CC   -!- FUNCTION: This protein is essential for phi-80 DNA synthesis.
CC   -!- MISCELLANEOUS: Presumably, its N-terminal half determines specific
CC       interaction with the replication origin on the phage DNA, while its C-
CC       terminal half binds specifically to the gene 14 protein.
CC   -!- SIMILARITY: Belongs to the phage O protein family. {ECO:0000305}.
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DR   EMBL; X13065; CAA31474.1; -; Genomic_DNA.
DR   EMBL; M10670; AAA32297.1; -; Genomic_DNA.
DR   PIR; S01776; ORBP15.
DR   RefSeq; YP_007947971.1; NC_021190.1.
DR   GeneID; 24366483; -.
DR   KEGG; vg:24366483; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR006497; Phage_lambda_VrpO_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04492; Phage_rep_O; 1.
DR   TIGRFAMs; TIGR01610; phage_O_Nterm; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Early protein.
FT   CHAIN           1..302
FT                   /note="Replication protein 15"
FT                   /id="PRO_0000077703"
FT   DNA_BIND        71..90
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   302 AA;  34333 MW;  5B5E82351AF36232 CRC64;
     MSNTAEIINF PNKTEQPGGR MADLSNGYTK VANEIQQLKP RLRLSGREWQ CFEAVIWLTY
     GWNKKQDRVT NTVIAELTGL SDTHVSDALK SLAERKIIFS QKQGMMKIVG VNTDLSAWIL
     DKPETGRKFP KTGKSFPKSG ITFPKTVDTQ YKNKNSIKRS SSENSDESSD ARLKKFLSTH
     PEAAVYTPSG AKWGSAEDLE TAKWISSRVK LINPTCKAPD MTSWSNTVRL MRQIDNRSHQ
     DICALYDWAS KHHFWQTNIL SPESLRKQWD KLTMQRNAGG EQRAVKPDLD FNNTDWAYGV
     IR