ID   VG16_SHV21              Reviewed;         160 AA.
AC   Q01001;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Bcl-2-like gene 16 protein;
GN   Name=16;
OS   Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=10383;
OH   NCBI_TaxID=9521; Saimiri sciureus (Common squirrel monkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1321287; DOI=10.1128/jvi.66.8.5047-5058.1992;
RA   Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B.,
RA   Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B.,
RA   Honess R.W.;
RT   "Primary structure of the herpesvirus saimiri genome.";
RL   J. Virol. 66:5047-5058(1992).
CC   -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR   EMBL; X64346; CAA45639.1; -; Genomic_DNA.
DR   RefSeq; NP_040218.1; NC_001350.1.
DR   GeneID; 1682512; -.
DR   KEGG; vg:1682512; -.
DR   Proteomes; UP000000587; Genome.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   SMART; SM00337; BCL; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein;
KW   Modulation of host cell apoptosis by virus; Reference proteome.
FT   CHAIN           1..160
FT                   /note="Bcl-2-like gene 16 protein"
FT                   /id="PRO_0000143092"
FT   MOTIF           64..84
FT                   /note="BH1"
SQ   SEQUENCE   160 AA;  17970 MW;  783980BF22B1184E CRC64;
     MSSIKFQNII ENILKKCQDN RHSQDSVVRA VHSVIHQYNK FEALMPDFSL CVHDRIKFTG
     EAILLTTEHT TNWGKVVAML SFSAAVLQTI DEEYKCVATS MLSSYISRSV GANWFIENGG
     EKSLVEFCNS IMPQNPFNVL NFLVPAVLAG LVLMQTLLIK