ID   VG36_ALHV1              Reviewed;         454 AA.
AC   O36385;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Putative tyrosine kinase 36;
DE            EC=2.7.10.2;
GN   Name=36;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. {ECO:0000305}.
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DR   EMBL; AF005370; AAC58082.1; -; Genomic_DNA.
DR   PIR; T03130; T03130.
DR   RefSeq; NP_065534.1; NC_002531.1.
DR   GeneID; 911800; -.
DR   KEGG; vg:911800; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase;
KW   Tyrosine-protein kinase.
FT   CHAIN           1..454
FT                   /note="Putative tyrosine kinase 36"
FT                   /id="PRO_0000405713"
FT   ACT_SITE        192
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10028"
FT   BINDING         80..88
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         98
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   454 AA;  50929 MW;  0B652BD91CB45C57 CRC64;
     MEVNRLAYLT AMGSLRPPSP NGDWSKPQDA PHKSVIDMMA SGVSHIKVLK VDIDAQHLCV
     CLPHNMLTCC HPAVDMENLL GSGSFGKVYA SGPGICAKVF TSAEAFYHET VMMDLVALAR
     SYNCDDFKSV CLQFYLSACV TCKTIWYPRF SQSLHTFKDF TVDHLHDLDR EFKGLTDAVF
     FLNQKCGLFH GDICPSNILV ETFKGPGSGI KSLILTDLGT AAIHAGNTFK SLSINNPQDD
     SVIYNAQIYL SPFLVCKDYV KPLCVLRRCY LLRHHAQDVD VEEITDTVVG QNMALKIDCS
     TLLQVLLLVL ARVMEQPNSL TYESWLREIE DDSSDAYFLL LLGPKLVLLT HLSQLWEINF
     DVGVNTQGVL SRGQLPHPHT RLLKECCQLF REEFDAVVKE EVLIKLGQGV LKNIIFELLQ
     FDYFEIHGRQ PQHGLFAQSH AARADSEHGN WRTS