ID   VG47_ICHVA              Reviewed;         370 AA.
AC   Q00139;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Subtilisin-like protease;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
GN   Name=ORF47;
OS   Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish
OS   herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Alloherpesviridae; Ictalurivirus.
OX   NCBI_TaxID=766178;
OH   NCBI_TaxID=7996; Ictaluridae (bullhead catfishes).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1727613; DOI=10.1016/0042-6822(92)90056-u;
RA   Davison A.J.;
RT   "Channel catfish virus: a new type of herpesvirus.";
RL   Virology 186:9-14(1992).
RN   [2]
RP   SEQUENCE REVISION.
RA   Davison A.J.;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
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DR   EMBL; M75136; AAA88150.2; -; Genomic_DNA.
DR   PIR; C36791; PRBEI1.
DR   RefSeq; NP_041138.2; NC_001493.2.
DR   SMR; Q00139; -.
DR   PRIDE; Q00139; -.
DR   GeneID; 1488436; -.
DR   KEGG; vg:1488436; -.
DR   Proteomes; UP000007643; Genome.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   Pfam; PF01483; P_proprotein; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protease; Reference proteome; Serine protease; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..370
FT                   /note="Subtilisin-like protease"
FT                   /id="PRO_0000076426"
FT   DOMAIN          18..261
FT                   /note="Peptidase S8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   DOMAIN          240..370
FT                   /note="P/Homo B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01173"
FT   ACT_SITE        13
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        35
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        190
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   370 AA;  39886 MW;  494B6216ECF4925D CRC64;
     MIASIVFFIV LVDGVATGSP NALVTDFDCR PGMKHCGVCQ QLISGSTGAN ALCSYKGVGD
     FIVNNFSMGP VDWLWPSTAP SYAVVSESWG CVDDGAAFCD TTGNFRDHRG RVAREGRDGL
     GTVLIRPAGN GGPIDDCGAD GFTQAIGTVV TTVTDYTRSE RCAAVLVTVP PPNETVWYDG
     KCGFIPSSSS AAPPILGNML LALIRAHPTL TLRMIQRILV RAAKPVTVTG WRGRGWWLNR
     VTDRWTHRNF GFGEVSPSRL EIEARRELST SRAPVAWSTL DTCDLSEVEW VRVRLGIAPA
     VFRGGVTVEI SSPSGTIIEI LGKRPLDFSR DEFEGEFVTP FWGEPGRGKW TVSCTGGVIL
     TTEGTCHGIR