ID   VG74_EHV2               Reviewed;         330 AA.
AC   Q66673;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=G-protein coupled receptor 74;
GN   Name=74;
OS   Equine herpesvirus 2 (strain 86/87) (EHV-2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Percavirus.
OX   NCBI_TaxID=82831;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7783207; DOI=10.1006/jmbi.1995.0314;
RA   Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus 2.";
RL   J. Mol. Biol. 249:520-528(1995).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U20824; AAC13861.1; -; Genomic_DNA.
DR   PIR; S55595; S55595.
DR   RefSeq; NP_042670.1; NC_001650.2.
DR   SMR; Q66673; -.
DR   GeneID; 1461030; -.
DR   KEGG; vg:1461030; -.
DR   Proteomes; UP000007083; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; G-protein coupled receptor; Host membrane; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="G-protein coupled receptor 74"
FT                   /id="PRO_0000405981"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DISULFID        117..195
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   330 AA;  37794 MW;  E1B8A057A368A19D CRC64;
     MESGSGSGAA LNSTPFPTYS TPNFTDDYDW NSSDWYGLTN QCQAVSFSKL IVVPCLVILL
     VFCLIGNLWL LFKLLEKTVK KVSTFILILM CLNSFWGCLC MIFSIVENFA EFSTSVCKLR
     MVVFWVYVFF DMFLICWLCF DTWCAVWFSV RRTEANQKCW VFCTVALIIL AFILSMQKAL
     HVEAIKEYGQ VRSSCQFHKE THSTLKVFNV AVSVNVLGFL LPLLFLCIFY GMCLWKLYKA
     VFKTKTKVIK TMLLFVFMFL LTWGPYYILS FIDGLLSAGY ISESCSLKKT LGLMLPLLGL
     WGMAHGGLQV FIYILCNSHF NKSLFSCFKK