ID   VGA5_ALHV1              Reviewed;         302 AA.
AC   O36364;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=G-protein coupled receptor A5;
GN   Name=A5;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=18024890; DOI=10.1099/vir.0.83153-0;
RA   Boudry C., Markine-Goriaynoff N., Delforge C., Springael J.Y., de Leval L.,
RA   Drion P., Russell G., Haig D.M., Vanderplasschen A.F., Dewals B.;
RT   "The A5 gene of alcelaphine herpesvirus 1 encodes a constitutively active
RT   G-protein-coupled receptor that is non-essential for the induction of
RT   malignant catarrhal fever in rabbits.";
RL   J. Gen. Virol. 88:3224-3233(2007).
CC   -!- FUNCTION: Acts as a viral G-protein coupled receptor that
CC       constitutively activates host alphai-type G-proteins, thereby
CC       inhibiting host forskolin-triggered CREB activation.
CC       {ECO:0000269|PubMed:18024890}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000269|PubMed:18024890}.
CC       Host endoplasmic reticulum membrane {ECO:0000269|PubMed:18024890}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AF005370; AAC58061.1; -; Genomic_DNA.
DR   PIR; T03109; T03109.
DR   RefSeq; NP_065513.1; NC_002531.1.
DR   SMR; O36364; -.
DR   GeneID; 911749; -.
DR   KEGG; vg:911749; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Host cell membrane; Host endoplasmic reticulum;
KW   Host membrane; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..302
FT                   /note="G-protein coupled receptor A5"
FT                   /id="PRO_0000405748"
FT   TOPO_DOM        1..20
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..50
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..173
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        195..208
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..249
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        271..302
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   302 AA;  33977 MW;  A5BF3A64349D0752 CRC64;
     MADSSNSSLN CTAIHDQTVL ILGQVFNSVW LFISVIFLYI FACKLCFRPR IYLWLSFYTL
     GFMLWVLCKV LQEYVTGKFK CVITNCIGDF CLVFLSCIML GIMLDRYLKI QGTLRGGMKD
     IHIGIFVSAS CFGSLMIALL DGLHMGDSEK LQFNGTESFK CLPATSVSSY KAQLMFKSIF
     CIICIIMCLI LTCLTAKKVL GTRLRKKYVI VGNVGLLSFV NILLWVMIAC GLLKQALESN
     LSLCPTKQST YIYPYTMPVT VIFVLVIYLF SSTHMKNAMR KSGQIRHSLS SPNQVQSSFR
     LV