ID   VGA9_ALHV1              Reviewed;         168 AA.
AC   O36423;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   29-SEP-2021, entry version 54.
DE   RecName: Full=Putative apoptosis regulator A9;
GN   Name=A9;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
CC   -!- FUNCTION: Suppresses apoptosis in host cell and thus facilitates
CC       production of progeny virions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AF005370; AAC58120.1; -; Genomic_DNA.
DR   PIR; T03168; T03168.
DR   RefSeq; NP_065572.1; NC_002531.1.
DR   SMR; O36423; -.
DR   GeneID; 911775; -.
DR   KEGG; vg:911775; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   SUPFAM; SSF56854; SSF56854; 1.
PE   3: Inferred from homology;
KW   Host membrane; Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein; Membrane;
KW   Modulation of host cell apoptosis by virus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..168
FT                   /note="Putative apoptosis regulator A9"
FT                   /id="PRO_0000405773"
FT   TRANSMEM        143..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   168 AA;  19555 MW;  495F908273049A87 CRC64;
     MKMLGEPEFK ENILYYSFLN ELFLILIRNG FSCSHAKLIL DETRKRGLEC SGQFEVISNS
     VEAPEPESLE RIAKTLFTPR PHWGRLVAFL AYLAYLQKNS TEKLFWNDHL KKLKQIVKCH
     IVPWTLGPRD PKPKQRPFDK LPSAFYFLTA AASCLTLLLL YFRTTQTK