ID   VGCR_HHV6Z              Reviewed;         205 AA.
AC   Q9QJ51;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=G-protein coupled receptor;
GN   Name=U12;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7687803; DOI=10.1006/viro.1993.1403;
RA   Pellett P.E., Sanchez-Martinez D., Dominguez G., Black J.B., Anton E.,
RA   Greenamoyer C., Dambaugh T.R.;
RT   "A strongly immunoreactive virion protein of human herpesvirus 6 variant B
RT   strain Z29: identification and characterization of the gene and mapping of
RT   a variant-specific monoclonal antibody reactive epitope.";
RL   Virology 195:521-531(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF157706; AAD49690.1; -; Genomic_DNA.
DR   RefSeq; NP_050193.1; NC_000898.1.
DR   SMR; Q9QJ51; -.
DR   PRIDE; Q9QJ51; -.
DR   DNASU; 1497022; -.
DR   GeneID; 1497022; -.
DR   KEGG; vg:1497022; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; G-protein coupled receptor; Host membrane; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..205
FT                   /note="G-protein coupled receptor"
FT                   /id="PRO_0000408446"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DISULFID        105..181
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   205 AA;  23253 MW;  1700AABF187615AD CRC64;
     MDTVIELSKL LHDEEFKDNA SCTSTPTLKT ARIIESAVTG ITLTASVPMI IIVITTMILY
     HRVAKHNATS FYVITLFASD FVLMWCVFFM TVNREQLFSF NRFFCQLVYF IYHAVCSYSI
     SMLAIIATIR YKTLHRRKQT ESKTYSTGRN IGILLLASSM CAIPTALFVQ INGAKKTTGK
     CVVYLSSPKA YELFLAVKIV FSFIW