VGE1_EHV2
ID VGE1_EHV2 Reviewed; 383 AA.
AC Q89609;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 23-FEB-2022, entry version 87.
DE RecName: Full=G-protein coupled receptor E1;
GN Name=E1;
OS Equine herpesvirus 2 (strain 86/87) (EHV-2).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Gammaherpesvirinae; Percavirus.
OX NCBI_TaxID=82831;
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=7783207; DOI=10.1006/jmbi.1995.0314;
RA Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.;
RT "The DNA sequence of equine herpesvirus 2.";
RL J. Mol. Biol. 249:520-528(1995).
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U20824; AAC13788.1; -; Genomic_DNA.
DR EMBL; U20824; AAC13866.1; -; Genomic_DNA.
DR PIR; S55594; S55594.
DR RefSeq; NP_042597.1; NC_001650.2.
DR RefSeq; NP_042675.1; NC_001650.2.
DR SMR; Q89609; -.
DR PRIDE; Q89609; -.
DR GeneID; 1461016; -.
DR GeneID; 1461067; -.
DR KEGG; vg:1461016; -.
DR KEGG; vg:1461067; -.
DR Proteomes; UP000007083; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:InterPro.
DR InterPro; IPR002236; Chemokine_CCR1.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01106; CHEMOKINER1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; G-protein coupled receptor; Host membrane; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..383
FT /note="G-protein coupled receptor E1"
FT /id="PRO_0000405982"
FT TRANSMEM 13..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DISULFID 145..222
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 383 AA; 43668 MW; 0C65C53EAF539F72 CRC64;
MATTSATSTV NTSSLATTMT TNFTSLLTSV VTTIASLVPS TNSSEDYYDD LDDVDYEESA
PCYKSDTTRL AAQVVPALYL LVFLFGLLGN ILVVIIVIRY MKIKNLTNML LLNLAISDLL
FLLTLPFWMH YIGMYHDWTF GISLCKLLRG VCYMSLYSQV FCIILLTVDR YLAVVYAVTA
LRFRTVTCGI VTCVCTWFLA GLLSLPEFFF HGHQDDNGRV QCDPYYPEMS TNVWRRAHVA
KVIMLSLILP LLIMAVCYYV IIRRLLRRPS KKKYKAIRLI FVIMVAYFVF WTPYNIVLLL
STFHATLLNL QCALSSNLDM ALLITKTVAY THCCINPVIY AFVGEKFRRH LYHFFHTYVA
IYLCKYIPFL SGDGEGKEGP TRI
