VGLG_HMPVC
ID VGLG_HMPVC Reviewed; 219 AA.
AC Q6WB94;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 52.
DE RecName: Full=Major surface glycoprotein G;
DE AltName: Full=Attachment glycoprotein G;
DE AltName: Full=Membrane-bound glycoprotein;
DE Short=mG;
GN Name=G;
OS Human metapneumovirus (strain CAN97-83) (HMPV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Pneumoviridae; Metapneumovirus.
OX NCBI_TaxID=694067;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=14592754; DOI=10.1016/s0042-6822(03)00528-2;
RA Biacchesi S., Skiadopoulos M.H., Boivin G., Hanson C.T., Murphy B.R.,
RA Collins P.L., Buchholz U.J.;
RT "Genetic diversity between human metapneumovirus subgroups.";
RL Virology 315:1-9(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=16306583; DOI=10.1128/jvi.79.24.15114-15122.2005;
RA Pham Q.N., Biacchesi S., Skiadopoulos M.H., Murphy B.R., Collins P.L.,
RA Buchholz U.J.;
RT "Chimeric recombinant human metapneumoviruses with the nucleoprotein or
RT phosphoprotein open reading frame replaced by that of avian metapneumovirus
RT exhibit improved growth in vitro and attenuation in vivo.";
RL J. Virol. 79:15114-15122(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=14993653; DOI=10.1099/vir.0.19504-0;
RA Peret T.C., Abed Y., Anderson L.J., Erdman D.D., Boivin G.;
RT "Sequence polymorphism of the predicted human metapneumovirus G
RT glycoprotein.";
RL J. Gen. Virol. 85:679-686(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA Peret T.C.T., Abed Y., Erdman D.D., Anderson L.J., Boivin G.;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH HOST DDX58.
RX PubMed=18516301; DOI=10.1371/journal.ppat.1000077;
RA Bao X., Liu T., Shan Y., Li K., Garofalo R.P., Casola A.;
RT "Human metapneumovirus glycoprotein G inhibits innate immune responses.";
RL PLoS Pathog. 4:E1000077-E1000077(2008).
RN [6]
RP FUNCTION.
RX PubMed=18786997; DOI=10.1128/jvi.01208-08;
RA Thammawat S., Sadlon T.A., Hallsworth P.G., Gordon D.L.;
RT "Role of cellular glycosaminoglycans and charged regions of viral G protein
RT in human metapneumovirus infection.";
RL J. Virol. 82:11767-11774(2008).
CC -!- FUNCTION: Attaches the virion to the host cell membrane by interacting
CC with glycosaminoglycans, initiating the infection. Unlike other
CC paramyxovirus attachment proteins, lacks both neuraminidase and
CC hemagglutinating activities. In addition to its role in attachment,
CC glycoprotein G interacts with host DDX58 and inhibits DDX58-mediated
CC signaling pathway in order to prevent the establishment of the
CC antiviral state. {ECO:0000269|PubMed:18786997}.
CC -!- SUBUNIT: Homooligomer. Interacts (via N-terminus) with protein M.
CC Interacts with protein F; this interaction occurs on the surface of
CC infected cells. Interacts with protein SH (By similarity). Interacts
CC with host DDX58; this interaction inhibits host immune response.
CC {ECO:0000250, ECO:0000269|PubMed:18516301}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}. Virion.
CC -!- SIMILARITY: Belongs to the metapneumoviruses glycoprotein G family.
CC {ECO:0000305}.
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DR EMBL; AY297749; AAQ67699.1; -; Genomic_RNA.
DR EMBL; AY485253; AAS48485.1; -; Genomic_RNA.
DR RefSeq; YP_012612.1; NC_004148.2.
DR IntAct; Q6WB94; 2.
DR PRIDE; Q6WB94; -.
DR Proteomes; UP000001398; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0039540; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR InterPro; IPR018585; Metaviral_G_glycop.
DR Pfam; PF09595; Metaviral_G; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Host membrane; Host-virus interaction;
KW Inhibition of host innate immune response by virus;
KW Inhibition of host RIG-I by virus; Inhibition of host RLR pathway by virus;
KW Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix; Viral attachment to host cell; Viral immunoevasion;
KW Virion; Virus entry into host cell.
FT CHAIN 1..219
FT /note="Major surface glycoprotein G"
FT /id="PRO_0000394814"
FT TOPO_DOM 1..30
FT /note="Intravirion"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..219
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT REGION 58..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 219 AA; 23668 MW; 5BB6EF50C14FF917 CRC64;
MEVKVENIRA IDMLKARVKN RVARSKCFKN ASLILIGITT LSIALNIYLI INYTIQKTSS
ESEHHTSSPP TESNKEASTI STDNPDINPN SQHPTQQSTE NPTLNPAASV SPSETEPAST
PDTTNRLSSV DRSTAQPSES RTKTKPTVHT RNNPSTASST QSPPRATTKA IRRATTFRMS
STGKRPTTTS VQSDSSTTTQ NHEETGSANP QASVSTMQN
