VGLL1_HUMAN
ID VGLL1_HUMAN Reviewed; 258 AA.
AC Q99990; Q5H915;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Transcription cofactor vestigial-like protein 1;
DE Short=Vgl-1;
DE AltName: Full=Protein TONDU;
GN Name=VGLL1; Synonyms=TDU;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH TEFS.
RX PubMed=10518497; DOI=10.1242/dev.126.21.4807;
RA Vaudin P., Delanoue R., Davidson I., Silber J., Zider A.;
RT "TONDU (TDU), a novel human protein related to the product of vestigial
RT (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors
RT and substitutes for Vg function in wing formation.";
RL Development 126:4807-4816(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a specific coactivator for the mammalian TEFs.
CC {ECO:0000269|PubMed:10518497}.
CC -!- SUBUNIT: Interacts with TEFs. {ECO:0000269|PubMed:10518497}.
CC -!- INTERACTION:
CC Q99990; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-11983165, EBI-8643161;
CC Q99990; P55273: CDKN2D; NbExp=3; IntAct=EBI-11983165, EBI-745859;
CC Q99990; P52597: HNRNPF; NbExp=3; IntAct=EBI-11983165, EBI-352986;
CC Q99990; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-11983165, EBI-2341787;
CC Q99990; O14770-4: MEIS2; NbExp=3; IntAct=EBI-11983165, EBI-8025850;
CC Q99990; Q99471: PFDN5; NbExp=3; IntAct=EBI-11983165, EBI-357275;
CC Q99990; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-11983165, EBI-10226430;
CC Q99990; Q15562-2: TEAD2; NbExp=3; IntAct=EBI-11983165, EBI-9370956;
CC Q99990; Q99594: TEAD3; NbExp=4; IntAct=EBI-11983165, EBI-746720;
CC Q99990; Q15561: TEAD4; NbExp=3; IntAct=EBI-11983165, EBI-747736;
CC Q99990; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-11983165, EBI-750487;
CC Q99990; Q08117-2: TLE5; NbExp=3; IntAct=EBI-11983165, EBI-11741437;
CC Q99990; P36406: TRIM23; NbExp=3; IntAct=EBI-11983165, EBI-740098;
CC Q99990; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-11983165, EBI-3918381;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the vestigial family. {ECO:0000305}.
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DR EMBL; AF137387; AAF13149.1; -; mRNA.
DR EMBL; AC000115; AAB46354.1; -; Genomic_DNA.
DR EMBL; Z97632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471150; EAW88467.1; -; Genomic_DNA.
DR EMBL; BC000045; AAH00045.1; -; mRNA.
DR EMBL; BC003362; AAH03362.1; -; mRNA.
DR CCDS; CCDS14658.1; -.
DR RefSeq; NP_057351.1; NM_016267.3.
DR AlphaFoldDB; Q99990; -.
DR SMR; Q99990; -.
DR BioGRID; 119544; 15.
DR IntAct; Q99990; 14.
DR STRING; 9606.ENSP00000359668; -.
DR iPTMnet; Q99990; -.
DR PhosphoSitePlus; Q99990; -.
DR BioMuta; VGLL1; -.
DR DMDM; 50401655; -.
DR EPD; Q99990; -.
DR MassIVE; Q99990; -.
DR MaxQB; Q99990; -.
DR PaxDb; Q99990; -.
DR PeptideAtlas; Q99990; -.
DR PRIDE; Q99990; -.
DR ProteomicsDB; 78565; -.
DR Antibodypedia; 16686; 137 antibodies from 23 providers.
DR DNASU; 51442; -.
DR Ensembl; ENST00000370634.8; ENSP00000359668.3; ENSG00000102243.13.
DR GeneID; 51442; -.
DR KEGG; hsa:51442; -.
DR MANE-Select; ENST00000370634.8; ENSP00000359668.3; NM_016267.4; NP_057351.1.
DR UCSC; uc004ezy.3; human.
DR CTD; 51442; -.
DR DisGeNET; 51442; -.
DR GeneCards; VGLL1; -.
DR HGNC; HGNC:20985; VGLL1.
DR HPA; ENSG00000102243; Tissue enriched (placenta).
DR MIM; 300583; gene.
DR neXtProt; NX_Q99990; -.
DR OpenTargets; ENSG00000102243; -.
DR PharmGKB; PA134923162; -.
DR VEuPathDB; HostDB:ENSG00000102243; -.
DR eggNOG; ENOG502S2FK; Eukaryota.
DR GeneTree; ENSGT00530000063353; -.
DR HOGENOM; CLU_078814_0_0_1; -.
DR InParanoid; Q99990; -.
DR OMA; NDSDMPP; -.
DR OrthoDB; 1146285at2759; -.
DR PhylomeDB; Q99990; -.
DR TreeFam; TF326340; -.
DR PathwayCommons; Q99990; -.
DR SignaLink; Q99990; -.
DR BioGRID-ORCS; 51442; 10 hits in 702 CRISPR screens.
DR ChiTaRS; VGLL1; human.
DR GenomeRNAi; 51442; -.
DR Pharos; Q99990; Tbio.
DR PRO; PR:Q99990; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q99990; protein.
DR Bgee; ENSG00000102243; Expressed in placenta and 75 other tissues.
DR ExpressionAtlas; Q99990; baseline and differential.
DR Genevisible; Q99990; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; TAS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR InterPro; IPR006627; TDU_repeat.
DR InterPro; IPR011520; Vg_fam.
DR PANTHER; PTHR15950; PTHR15950; 1.
DR Pfam; PF07545; Vg_Tdu; 1.
DR SMART; SM00711; TDU; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..258
FT /note="Transcription cofactor vestigial-like protein 1"
FT /id="PRO_0000191347"
FT REGION 55..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 59
FT /note="T -> I (in dbSNP:rs3027860)"
FT /id="VAR_053735"
SQ SEQUENCE 258 AA; 28707 MW; EA688B03E04AAD7F CRC64;
MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS NIKSPQELTP
SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA NCNLHVPGPM AVNQFSPSLA
RRASVRPGEL WHFSSLAGTS SLEPGYSHPF PARHLVPEPQ PDGKREPLLS LLQQDRCLAR
PQESAARENG NPGQIAGSTG LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY
SLTPPNHWGH PHRYLQHL
