ID   VGLL1_MOUSE             Reviewed;         307 AA.
AC   Q99NC0; A2AFJ9;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Transcription cofactor vestigial-like protein 1;
DE            Short=Vgl-1;
DE   AltName: Full=Vestigial-related factor;
GN   Name=Vgll1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ICR; TISSUE=Placenta;
RA   Yasunami M.;
RT   "Isolation of a cDNA encoding mouse vestigial-related factor that interacts
RT   with the TEAD family transcription factors.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: May act as a specific coactivator for the mammalian TEFs.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TEFs. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q99NC0; Q62296-1: Tead4; NbExp=4; IntAct=EBI-15985690, EBI-15985676;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vestigial family. {ECO:0000305}.
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DR   EMBL; AB036708; BAB40534.1; -; mRNA.
DR   EMBL; AL672128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS30151.1; -.
DR   RefSeq; NP_001300692.1; NM_001313763.1.
DR   RefSeq; NP_573514.1; NM_133251.2.
DR   PDB; 5Z2Q; X-ray; 2.74 A; C/D=20-51.
DR   PDBsum; 5Z2Q; -.
DR   AlphaFoldDB; Q99NC0; -.
DR   SMR; Q99NC0; -.
DR   DIP; DIP-59848N; -.
DR   IntAct; Q99NC0; 1.
DR   STRING; 10090.ENSMUSP00000033465; -.
DR   PhosphoSitePlus; Q99NC0; -.
DR   PaxDb; Q99NC0; -.
DR   PRIDE; Q99NC0; -.
DR   Antibodypedia; 16686; 137 antibodies from 23 providers.
DR   DNASU; 170828; -.
DR   Ensembl; ENSMUST00000033465; ENSMUSP00000033465; ENSMUSG00000031131.
DR   Ensembl; ENSMUST00000114745; ENSMUSP00000110393; ENSMUSG00000031131.
DR   Ensembl; ENSMUST00000114746; ENSMUSP00000110394; ENSMUSG00000031131.
DR   GeneID; 170828; -.
DR   KEGG; mmu:170828; -.
DR   UCSC; uc009tgz.1; mouse.
DR   CTD; 51442; -.
DR   MGI; MGI:2655768; Vgll1.
DR   VEuPathDB; HostDB:ENSMUSG00000031131; -.
DR   eggNOG; ENOG502S2FK; Eukaryota.
DR   GeneTree; ENSGT00530000063353; -.
DR   HOGENOM; CLU_078814_0_0_1; -.
DR   InParanoid; Q99NC0; -.
DR   OMA; ESMIKQE; -.
DR   OrthoDB; 1146285at2759; -.
DR   PhylomeDB; Q99NC0; -.
DR   TreeFam; TF326340; -.
DR   BioGRID-ORCS; 170828; 4 hits in 73 CRISPR screens.
DR   PRO; PR:Q99NC0; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q99NC0; protein.
DR   Bgee; ENSMUSG00000031131; Expressed in animal zygote and 12 other tissues.
DR   ExpressionAtlas; Q99NC0; baseline and differential.
DR   Genevisible; Q99NC0; MM.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IPI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR011520; Vg_fam.
DR   PANTHER; PTHR15950; PTHR15950; 2.
DR   Pfam; PF07545; Vg_Tdu; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..307
FT                   /note="Transcription cofactor vestigial-like protein 1"
FT                   /id="PRO_0000191348"
FT   REGION          55..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          20..24
FT                   /evidence="ECO:0007829|PDB:5Z2Q"
FT   STRAND          27..31
FT                   /evidence="ECO:0007829|PDB:5Z2Q"
FT   HELIX           37..49
FT                   /evidence="ECO:0007829|PDB:5Z2Q"
SQ   SEQUENCE   307 AA;  34691 MW;  1AC4714CF93C27E9 CRC64;
     MEEMKKNGVW IPESSQKPVK TEWNAGSVIF TYFEGDINSM VDEHFSRALR NLKRPHKCSS
     SSHSDNLTLK NGVNKTRTDT SHTDRERKVE SSQTENSGEL KDVPVEEKGT NKSMPPNQRH
     LSSWTIAQPA ASPENGARSS SLDEYGLKAM DQHSLSMPKT PSALPLEPWH FSSLARPGFI
     APAYFPVFPD RHLTPEVYRV FPDRHLTPEV YHVFPDRHLT PEVYPDGRCG PLQHLVQQDR
     YQNHPLEPAA RENCSPAKIA GSTGSLMNLP PYPVHYKKKI CARGAASASL DDERSPSPKR
     RRDAYYY