VGLL2_HUMAN
ID VGLL2_HUMAN Reviewed; 317 AA.
AC Q8N8G2; Q8WWX1;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Transcription cofactor vestigial-like protein 2;
DE Short=Vgl-2;
DE AltName: Full=Protein VITO1;
GN Name=VGLL2; Synonyms=VITO1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=12617818; DOI=10.1016/s0925-4773(02)00386-6;
RA Mielcarek M., Gunther S., Kruger M., Braun T.;
RT "VITO-1, a novel vestigial related protein is predominantly expressed in
RT the skeletal muscle lineage.";
RL Gene Expr. Patterns 2:305-310(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=12376544; DOI=10.1074/jbc.m206858200;
RA Maeda T., Chapman D.L., Stewart A.F.R.;
RT "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription
RT factors that promotes skeletal muscle differentiation.";
RL J. Biol. Chem. 277:48889-48898(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a specific coactivator for the mammalian TEFs. May
CC play a role in the development of skeletal muscles.
CC -!- SUBUNIT: Interacts with TEFs. Binds to TEAD1/TEF1.
CC -!- INTERACTION:
CC Q8N8G2; Q99594: TEAD3; NbExp=3; IntAct=EBI-10267981, EBI-746720;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N8G2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N8G2-2; Sequence=VSP_032166;
CC -!- TISSUE SPECIFICITY: Skeletal muscle. {ECO:0000269|PubMed:12617818}.
CC -!- SIMILARITY: Belongs to the vestigial family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ578053; CAE17331.1; -; mRNA.
DR EMBL; AY056583; AAL17720.1; -; mRNA.
DR EMBL; AK096878; BAC04881.1; -; mRNA.
DR EMBL; Z98880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48211.1; -; Genomic_DNA.
DR EMBL; BC069316; AAH69316.1; -; mRNA.
DR EMBL; BC100798; AAI00799.1; -; mRNA.
DR EMBL; BC100799; AAI00800.1; -; mRNA.
DR EMBL; BC118545; AAI18546.1; -; mRNA.
DR EMBL; BC118622; AAI18623.1; -; mRNA.
DR CCDS; CCDS5114.1; -. [Q8N8G2-2]
DR CCDS; CCDS5115.1; -. [Q8N8G2-1]
DR RefSeq; NP_703154.1; NM_153453.1. [Q8N8G2-2]
DR RefSeq; NP_872586.1; NM_182645.3. [Q8N8G2-1]
DR AlphaFoldDB; Q8N8G2; -.
DR BioGRID; 128830; 2.
DR IntAct; Q8N8G2; 1.
DR STRING; 9606.ENSP00000320957; -.
DR iPTMnet; Q8N8G2; -.
DR PhosphoSitePlus; Q8N8G2; -.
DR BioMuta; VGLL2; -.
DR DMDM; 50401602; -.
DR MassIVE; Q8N8G2; -.
DR PaxDb; Q8N8G2; -.
DR PeptideAtlas; Q8N8G2; -.
DR PRIDE; Q8N8G2; -.
DR Antibodypedia; 32540; 205 antibodies from 25 providers.
DR DNASU; 245806; -.
DR Ensembl; ENST00000326274.6; ENSP00000320957.5; ENSG00000170162.14. [Q8N8G2-1]
DR Ensembl; ENST00000352536.7; ENSP00000305405.5; ENSG00000170162.14. [Q8N8G2-2]
DR GeneID; 245806; -.
DR KEGG; hsa:245806; -.
DR MANE-Select; ENST00000326274.6; ENSP00000320957.5; NM_182645.3; NP_872586.1.
DR UCSC; uc003pxn.4; human. [Q8N8G2-1]
DR CTD; 245806; -.
DR DisGeNET; 245806; -.
DR GeneCards; VGLL2; -.
DR HGNC; HGNC:20232; VGLL2.
DR HPA; ENSG00000170162; Tissue enriched (skeletal).
DR MIM; 609979; gene.
DR neXtProt; NX_Q8N8G2; -.
DR OpenTargets; ENSG00000170162; -.
DR PharmGKB; PA134881890; -.
DR VEuPathDB; HostDB:ENSG00000170162; -.
DR eggNOG; ENOG502QS1A; Eukaryota.
DR GeneTree; ENSGT00530000063353; -.
DR HOGENOM; CLU_116340_0_0_1; -.
DR InParanoid; Q8N8G2; -.
DR OMA; HTELPFA; -.
DR OrthoDB; 1146285at2759; -.
DR PhylomeDB; Q8N8G2; -.
DR TreeFam; TF326340; -.
DR PathwayCommons; Q8N8G2; -.
DR SignaLink; Q8N8G2; -.
DR BioGRID-ORCS; 245806; 12 hits in 1071 CRISPR screens.
DR GenomeRNAi; 245806; -.
DR Pharos; Q8N8G2; Tbio.
DR PRO; PR:Q8N8G2; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8N8G2; protein.
DR Bgee; ENSG00000170162; Expressed in skeletal muscle tissue of rectus abdominis and 73 other tissues.
DR Genevisible; Q8N8G2; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR InterPro; IPR011520; Vg_fam.
DR PANTHER; PTHR15950; PTHR15950; 1.
DR Pfam; PF07545; Vg_Tdu; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..317
FT /note="Transcription cofactor vestigial-like protein 2"
FT /id="PRO_0000191349"
FT REGION 41..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 131..304
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12376544,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_032166"
SQ SEQUENCE 317 AA; 33426 MW; 2C08E5D1070FF10D CRC64;
MSCLDVMYQV YGPPQPYFAA AYTPYHQKLA YYSKMQEAQE CNASPSSSGS GSSSFSSQTP
ASIKEEEGSP EKERPPEAEY INSRCVLFTY FQGDISSVVD EHFSRALSQP SSYSPSCTSS
KAPRSSGPWR DCSFPMSQRS FPASFWNSAY QAPVPPPLGS PLATAHSELP FAAADPYSPA
ALHGHLHQGA TEPWHHAHPH HAHPHHPYAL GGALGAQAAP YPRPAAVHEV YAPHFDPRYG
PLLMPAASGR PARLATAPAP APGSPPCELS GKGEPAGAAW AGPGGPFASP SGDVAQGLGL
SVDSARRYSL CGASLLS
