VGLL2_MOUSE
ID VGLL2_MOUSE Reviewed; 322 AA.
AC Q8BGW8; Q8BWB4;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transcription cofactor vestigial-like protein 2;
DE Short=Vgl-2;
DE AltName: Full=Protein VITO1;
GN Name=Vgll2; Synonyms=Vgl2, Vito1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TEFS, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=C57BL/6J;
RX PubMed=12376544; DOI=10.1074/jbc.m206858200;
RA Maeda T., Chapman D.L., Stewart A.F.R.;
RT "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription
RT factors that promotes skeletal muscle differentiation.";
RL J. Biol. Chem. 277:48889-48898(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=12617818; DOI=10.1016/s0925-4773(02)00386-6;
RA Mielcarek M., Gunther S., Kruger M., Braun T.;
RT "VITO-1, a novel vestigial related protein is predominantly expressed in
RT the skeletal muscle lineage.";
RL Gene Expr. Patterns 2:305-310(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May act as a specific coactivator for the mammalian TEFs. May
CC play a role in the development of skeletal muscles.
CC {ECO:0000269|PubMed:12376544}.
CC -!- SUBUNIT: Interacts with TEFs. Binds to TEAD1/TEF1.
CC {ECO:0000269|PubMed:12376544}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12376544}.
CC -!- TISSUE SPECIFICITY: Skeletal muscle specific.
CC {ECO:0000269|PubMed:12617818}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the somitic myotome from 8.75 dpc
CC mouse embryos onwards and later on in skeletal muscle but not in the
CC heart. Additional expression domains during development are detected in
CC the pharyngeal pouches and clefts starting at 8.0 dpc as well as in the
CC cranial pharynx and in Rathkes pouch. {ECO:0000269|PubMed:12617818}.
CC -!- SIMILARITY: Belongs to the vestigial family. {ECO:0000305}.
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DR EMBL; AF542181; AAN37898.1; -; mRNA.
DR EMBL; AJ578054; CAE17332.1; -; mRNA.
DR EMBL; AK048390; BAC33319.1; -; mRNA.
DR EMBL; AK052987; BAC35232.1; -; mRNA.
DR CCDS; CCDS23837.1; -.
DR RefSeq; NP_001287886.1; NM_001300957.1.
DR RefSeq; NP_722481.1; NM_153786.2.
DR AlphaFoldDB; Q8BGW8; -.
DR BioGRID; 229591; 2.
DR STRING; 10090.ENSMUSP00000124091; -.
DR PhosphoSitePlus; Q8BGW8; -.
DR PaxDb; Q8BGW8; -.
DR PRIDE; Q8BGW8; -.
DR Antibodypedia; 32540; 205 antibodies from 25 providers.
DR DNASU; 215031; -.
DR Ensembl; ENSMUST00000163017; ENSMUSP00000124091; ENSMUSG00000049641.
DR GeneID; 215031; -.
DR KEGG; mmu:215031; -.
DR UCSC; uc007faz.2; mouse.
DR CTD; 245806; -.
DR MGI; MGI:2447460; Vgll2.
DR VEuPathDB; HostDB:ENSMUSG00000049641; -.
DR eggNOG; ENOG502QS1A; Eukaryota.
DR GeneTree; ENSGT00530000063353; -.
DR HOGENOM; CLU_056560_1_0_1; -.
DR InParanoid; Q8BGW8; -.
DR OMA; PSPDAWH; -.
DR OrthoDB; 1146285at2759; -.
DR PhylomeDB; Q8BGW8; -.
DR TreeFam; TF326340; -.
DR BioGRID-ORCS; 215031; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8BGW8; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8BGW8; protein.
DR Bgee; ENSMUSG00000049641; Expressed in soleus muscle and 89 other tissues.
DR Genevisible; Q8BGW8; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0008022; F:protein C-terminus binding; IPI:MGI.
DR GO; GO:0003713; F:transcription coactivator activity; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007519; P:skeletal muscle tissue development; IDA:MGI.
DR InterPro; IPR011520; Vg_fam.
DR PANTHER; PTHR15950; PTHR15950; 1.
DR Pfam; PF07545; Vg_Tdu; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..322
FT /note="Transcription cofactor vestigial-like protein 2"
FT /id="PRO_0000191350"
FT REGION 42..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 130
FT /note="Missing (in Ref. 3; BAC35232)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 322 AA; 34064 MW; 6869E34EC6AEAFD9 CRC64;
MSCLDVMYQV YGPPQPYFAA AYTPYHQKLA YYSKMQEAQE CASPGSSASG SSSFSNPTPA
SVKEEEGSPE KERPPEAEYI NSRCVLFTYF QGDISSVVDE HFSRALSHPS SYTPSCTSSK
AHRSSGPWRA EGTFPMSQRS FPASFWNSAY QAPVPAPLGS PLAAAHSELP FATDPYSPAT
LHGHLHQGAA DWHHAHPHHA HPHHPYALGG ALGAQASAYP RPAVHEVYAP HFDPRYGPLL
MPAATGRPGR LAPASAPAPG SPPCELAAKG EPAGSAWAAP GGPFVSPTGD VAQSLGLSVD
SGKRRRECSL PSAPPALYPT LG
