VGLL3_HUMAN
ID VGLL3_HUMAN Reviewed; 326 AA.
AC A8MV65; D3DU37; Q504T7;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transcription cofactor vestigial-like protein 3;
DE Short=Vgl-3;
GN Name=VGLL3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0000312|EMBL:EAW68870.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAH94780.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta {ECO:0000312|EMBL:AAH94780.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12376544; DOI=10.1074/jbc.m206858200;
RA Maeda T., Chapman D.L., Stewart A.F.R.;
RT "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription
RT factors that promotes skeletal muscle differentiation.";
RL J. Biol. Chem. 277:48889-48898(2002).
RN [5]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-62 AND LYS-126, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May act as a specific coactivator for the mammalian TEFs.
CC {ECO:0000250|UniProtKB:Q8N8G2}.
CC -!- INTERACTION:
CC A8MV65-2; Q6NVV7: CDPF1; NbExp=3; IntAct=EBI-11957216, EBI-2802782;
CC A8MV65-2; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-11957216, EBI-12261896;
CC A8MV65-2; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-11957216, EBI-12819063;
CC A8MV65-2; Q99895: CTRC; NbExp=3; IntAct=EBI-11957216, EBI-10295404;
CC A8MV65-2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11957216, EBI-3867333;
CC A8MV65-2; Q86UW9: DTX2; NbExp=3; IntAct=EBI-11957216, EBI-740376;
CC A8MV65-2; Q9NQ30: ESM1; NbExp=3; IntAct=EBI-11957216, EBI-12260294;
CC A8MV65-2; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-11957216, EBI-12193763;
CC A8MV65-2; O43559: FRS3; NbExp=3; IntAct=EBI-11957216, EBI-725515;
CC A8MV65-2; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-11957216, EBI-14103818;
CC A8MV65-2; O14964: HGS; NbExp=3; IntAct=EBI-11957216, EBI-740220;
CC A8MV65-2; Q0VD86: INCA1; NbExp=3; IntAct=EBI-11957216, EBI-6509505;
CC A8MV65-2; Q5T749: KPRP; NbExp=3; IntAct=EBI-11957216, EBI-10981970;
CC A8MV65-2; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11957216, EBI-11959885;
CC A8MV65-2; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11957216, EBI-10172290;
CC A8MV65-2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11957216, EBI-10171774;
CC A8MV65-2; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11957216, EBI-10172052;
CC A8MV65-2; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11957216, EBI-1052037;
CC A8MV65-2; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11957216, EBI-10210845;
CC A8MV65-2; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11957216, EBI-10176379;
CC A8MV65-2; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11957216, EBI-11953334;
CC A8MV65-2; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-11957216, EBI-11953846;
CC A8MV65-2; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-11957216, EBI-11992140;
CC A8MV65-2; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-11957216, EBI-12811111;
CC A8MV65-2; Q3LHN2: KRTAP19-2; NbExp=5; IntAct=EBI-11957216, EBI-12196745;
CC A8MV65-2; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-11957216, EBI-12805508;
CC A8MV65-2; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-11957216, EBI-10241353;
CC A8MV65-2; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-11957216, EBI-9996449;
CC A8MV65-2; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-11957216, EBI-3957694;
CC A8MV65-2; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11957216, EBI-10302392;
CC A8MV65-2; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11957216, EBI-10172511;
CC A8MV65-2; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11957216, EBI-11993296;
CC A8MV65-2; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11957216, EBI-10250562;
CC A8MV65-2; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-11957216, EBI-12111050;
CC A8MV65-2; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11957216, EBI-11962084;
CC A8MV65-2; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11957216, EBI-1044640;
CC A8MV65-2; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11957216, EBI-1043191;
CC A8MV65-2; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-11957216, EBI-11958364;
CC A8MV65-2; Q14847-2: LASP1; NbExp=3; IntAct=EBI-11957216, EBI-9088686;
CC A8MV65-2; Q96PV6: LENG8; NbExp=3; IntAct=EBI-11957216, EBI-739546;
CC A8MV65-2; Q99750: MDFI; NbExp=3; IntAct=EBI-11957216, EBI-724076;
CC A8MV65-2; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-11957216, EBI-12813389;
CC A8MV65-2; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-11957216, EBI-11956269;
CC A8MV65-2; P78337: PITX1; NbExp=3; IntAct=EBI-11957216, EBI-748265;
CC A8MV65-2; Q99697-2: PITX2; NbExp=3; IntAct=EBI-11957216, EBI-12138495;
CC A8MV65-2; O15496: PLA2G10; NbExp=3; IntAct=EBI-11957216, EBI-726466;
CC A8MV65-2; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-11957216, EBI-1389308;
CC A8MV65-2; Q16633: POU2AF1; NbExp=3; IntAct=EBI-11957216, EBI-943588;
CC A8MV65-2; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-11957216, EBI-740343;
CC A8MV65-2; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-11957216, EBI-6257312;
CC A8MV65-2; Q92922: SMARCC1; NbExp=3; IntAct=EBI-11957216, EBI-355653;
CC A8MV65-2; Q9H4F8-2: SMOC1; NbExp=3; IntAct=EBI-11957216, EBI-12162539;
CC A8MV65-2; Q96SF7: TBX15; NbExp=3; IntAct=EBI-11957216, EBI-10191361;
CC A8MV65-2; P28347-2: TEAD1; NbExp=3; IntAct=EBI-11957216, EBI-12151837;
CC A8MV65-2; Q15562-2: TEAD2; NbExp=3; IntAct=EBI-11957216, EBI-9370956;
CC A8MV65-2; Q99594: TEAD3; NbExp=3; IntAct=EBI-11957216, EBI-746720;
CC A8MV65-2; Q15561: TEAD4; NbExp=3; IntAct=EBI-11957216, EBI-747736;
CC A8MV65-2; Q96LM6: TEX37; NbExp=3; IntAct=EBI-11957216, EBI-743976;
CC A8MV65-2; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-11957216, EBI-5235829;
CC A8MV65-2; Q86WV8: TSC1; NbExp=3; IntAct=EBI-11957216, EBI-12806590;
CC A8MV65-2; O14817: TSPAN4; NbExp=3; IntAct=EBI-11957216, EBI-8652667;
CC A8MV65-2; Q6NVU6: UFSP1; NbExp=3; IntAct=EBI-11957216, EBI-12068150;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N8G2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A8MV65-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:15489334};
CC IsoId=A8MV65-2; Sequence=VSP_052713;
CC -!- TISSUE SPECIFICITY: Enriched in placenta.
CC {ECO:0000269|PubMed:12376544}.
CC -!- SIMILARITY: Belongs to the vestigial family. {ECO:0000255}.
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DR EMBL; AC108709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471110; EAW68870.1; -; Genomic_DNA.
DR EMBL; CH471110; EAW68871.1; -; Genomic_DNA.
DR EMBL; BC094780; AAH94780.1; -; mRNA.
DR CCDS; CCDS43110.1; -. [A8MV65-1]
DR CCDS; CCDS82807.1; -. [A8MV65-2]
DR RefSeq; NP_001307422.1; NM_001320493.1. [A8MV65-2]
DR RefSeq; NP_057290.2; NM_016206.3. [A8MV65-1]
DR AlphaFoldDB; A8MV65; -.
DR BioGRID; 132991; 69.
DR IntAct; A8MV65; 63.
DR STRING; 9606.ENSP00000381436; -.
DR iPTMnet; A8MV65; -.
DR PhosphoSitePlus; A8MV65; -.
DR BioMuta; VGLL3; -.
DR EPD; A8MV65; -.
DR MassIVE; A8MV65; -.
DR MaxQB; A8MV65; -.
DR PaxDb; A8MV65; -.
DR PeptideAtlas; A8MV65; -.
DR PRIDE; A8MV65; -.
DR ProteomicsDB; 2156; -. [A8MV65-1]
DR ProteomicsDB; 2157; -. [A8MV65-2]
DR Antibodypedia; 32031; 105 antibodies from 17 providers.
DR DNASU; 389136; -.
DR Ensembl; ENST00000383698.3; ENSP00000373199.3; ENSG00000206538.9. [A8MV65-2]
DR Ensembl; ENST00000398399.7; ENSP00000381436.2; ENSG00000206538.9. [A8MV65-1]
DR GeneID; 389136; -.
DR KEGG; hsa:389136; -.
DR MANE-Select; ENST00000398399.7; ENSP00000381436.2; NM_016206.4; NP_057290.2.
DR UCSC; uc003dqn.4; human. [A8MV65-1]
DR CTD; 389136; -.
DR DisGeNET; 389136; -.
DR GeneCards; VGLL3; -.
DR HGNC; HGNC:24327; VGLL3.
DR HPA; ENSG00000206538; Tissue enhanced (placenta).
DR MIM; 609980; gene.
DR neXtProt; NX_A8MV65; -.
DR OpenTargets; ENSG00000206538; -.
DR PharmGKB; PA142670628; -.
DR VEuPathDB; HostDB:ENSG00000206538; -.
DR eggNOG; ENOG502R6G3; Eukaryota.
DR GeneTree; ENSGT00530000063353; -.
DR HOGENOM; CLU_056560_0_0_1; -.
DR InParanoid; A8MV65; -.
DR OMA; AKTSVWF; -.
DR OrthoDB; 1146285at2759; -.
DR PhylomeDB; A8MV65; -.
DR TreeFam; TF326340; -.
DR PathwayCommons; A8MV65; -.
DR SignaLink; A8MV65; -.
DR BioGRID-ORCS; 389136; 20 hits in 1071 CRISPR screens.
DR ChiTaRS; VGLL3; human.
DR GenomeRNAi; 389136; -.
DR Pharos; A8MV65; Tbio.
DR PRO; PR:A8MV65; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A8MV65; protein.
DR Bgee; ENSG00000206538; Expressed in lower lobe of lung and 146 other tissues.
DR ExpressionAtlas; A8MV65; baseline and differential.
DR Genevisible; A8MV65; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR006627; TDU_repeat.
DR InterPro; IPR011520; Vg_fam.
DR PANTHER; PTHR15950; PTHR15950; 1.
DR Pfam; PF07545; Vg_Tdu; 1.
DR SMART; SM00711; TDU; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..326
FT /note="Transcription cofactor vestigial-like protein 3"
FT /id="PRO_0000324661"
FT REGION 57..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..78
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..249
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 62
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 126
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 314..326
FT /note="LQHQDKSKESPWY -> WSAMARS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_052713"
SQ SEQUENCE 326 AA; 36009 MW; 08D015C2A4297FE8 CRC64;
MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK MQDSLEVTLP
SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS VVDEHFSRAL GQAITLHPES
AISKSKMGLT PLWRDSSALS SQRNSFPTSF WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS
AADPSPWPGH NLHQTGPAPP PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH
RHHHHHHHPP AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG
TVDIVPSVGF DTGLQHQDKS KESPWY
