ID   VGLL3_MOUSE             Reviewed;         326 AA.
AC   P85442;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Transcription cofactor vestigial-like protein 3;
DE            Short=Vgl-3;
GN   Name=Vgll3 {ECO:0000312|MGI:MGI:1920819};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-326.
RC   TISSUE=Mammary tumor {ECO:0000269|PubMed:15489334};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May act as a specific coactivator for the mammalian TEFs.
CC       {ECO:0000250|UniProtKB:Q8N8G2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N8G2}.
CC   -!- SIMILARITY: Belongs to the vestigial family. {ECO:0000255}.
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DR   EMBL; CT010565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC042696; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_006523160.1; XM_006523097.3.
DR   AlphaFoldDB; P85442; -.
DR   STRING; 10090.ENSMUSP00000131500; -.
DR   PhosphoSitePlus; P85442; -.
DR   MaxQB; P85442; -.
DR   PaxDb; P85442; -.
DR   PRIDE; P85442; -.
DR   MGI; MGI:1920819; Vgll3.
DR   eggNOG; ENOG502R6G3; Eukaryota.
DR   InParanoid; P85442; -.
DR   OrthoDB; 1146285at2759; -.
DR   PhylomeDB; P85442; -.
DR   BioGRID-ORCS; 73569; 0 hits in 72 CRISPR screens.
DR   PRO; PR:P85442; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P85442; protein.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IPI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR006627; TDU_repeat.
DR   InterPro; IPR011520; Vg_fam.
DR   PANTHER; PTHR15950; PTHR15950; 1.
DR   Pfam; PF07545; Vg_Tdu; 1.
DR   SMART; SM00711; TDU; 1.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation.
FT   CHAIN           1..326
FT                   /note="Transcription cofactor vestigial-like protein 3"
FT                   /id="PRO_0000324662"
FT   REGION          54..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..81
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        62
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:A8MV65"
FT   CROSSLNK        129
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:A8MV65"
FT   CONFLICT        44
FT                   /note="Missing (in Ref. 2; BC042696)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   326 AA;  35999 MW;  B7682C9BCDBE70BA CRC64;
     MSCAEVMYHP QPYGAPQYLP NPVAAATCPT ACYHPAPQPG QQKKLAVYSK MQDSLEVTLP
     SKQEEEEEEE EDEEEEEKDQ PAEMEYLNSR CVLFTYFQGD IGSVVDEHFS RALGQANTLH
     PESAISKSKM GLTPLWRDSS ALSSQRSNFP TSFWTSSYQP PPAPCLGGVH PDFQVTAPHG
     TFTTADPNSW PGHGLHQTGP APPPTASESW HYPLASQVSP SYSHMHDMYL RHHHPHAHVH
     HRHHHHHHPT AGSALDPAYG HLLMPSVRAA RIPAPQCDIT KTDLTTVTTA TSAWAGAFHG
     TVDIVPSVGF DTGLQHQDKS KESTWY