VGLL4_MOUSE
ID VGLL4_MOUSE Reviewed; 287 AA.
AC Q80V24;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Transcription cofactor vestigial-like protein 4;
DE Short=Vgl-4;
GN Name=Vgll4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a specific coactivator for the mammalian TEFs.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TEFs. Interacts with IRF2BP2 (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q80V24; Q62296: Tead4; NbExp=3; IntAct=EBI-9253433, EBI-9253444;
CC Q80V24; Q15561: TEAD4; Xeno; NbExp=3; IntAct=EBI-9253433, EBI-747736;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the vestigial family. {ECO:0000305}.
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DR EMBL; BC048841; AAH48841.1; -; mRNA.
DR EMBL; BC060305; AAH60305.1; -; mRNA.
DR CCDS; CCDS20436.1; -.
DR RefSeq; NP_808351.1; NM_177683.2.
DR PDB; 4LN0; X-ray; 2.90 A; C=203-256.
DR PDB; 6SBA; X-ray; 1.30 A; B=233-252.
DR PDBsum; 4LN0; -.
DR PDBsum; 6SBA; -.
DR AlphaFoldDB; Q80V24; -.
DR SMR; Q80V24; -.
DR BioGRID; 231240; 1.
DR IntAct; Q80V24; 2.
DR STRING; 10090.ENSMUSP00000032459; -.
DR iPTMnet; Q80V24; -.
DR PhosphoSitePlus; Q80V24; -.
DR jPOST; Q80V24; -.
DR MaxQB; Q80V24; -.
DR PaxDb; Q80V24; -.
DR PeptideAtlas; Q80V24; -.
DR PRIDE; Q80V24; -.
DR ProteomicsDB; 297881; -.
DR Antibodypedia; 26100; 164 antibodies from 24 providers.
DR Ensembl; ENSMUST00000032459; ENSMUSP00000032459; ENSMUSG00000030315.
DR GeneID; 232334; -.
DR KEGG; mmu:232334; -.
DR UCSC; uc009dif.2; mouse.
DR CTD; 9686; -.
DR MGI; MGI:2652840; Vgll4.
DR VEuPathDB; HostDB:ENSMUSG00000030315; -.
DR eggNOG; ENOG502QTV3; Eukaryota.
DR GeneTree; ENSGT00390000003282; -.
DR HOGENOM; CLU_085402_0_0_1; -.
DR InParanoid; Q80V24; -.
DR OMA; CYEGEAS; -.
DR OrthoDB; 1275581at2759; -.
DR PhylomeDB; Q80V24; -.
DR TreeFam; TF330846; -.
DR BioGRID-ORCS; 232334; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Vgll4; mouse.
DR PRO; PR:Q80V24; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q80V24; protein.
DR Bgee; ENSMUSG00000030315; Expressed in rostral migratory stream and 188 other tissues.
DR ExpressionAtlas; Q80V24; baseline and differential.
DR Genevisible; Q80V24; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001223; F:transcription coactivator binding; IBA:GO_Central.
DR GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IMP:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR GO; GO:0035331; P:negative regulation of hippo signaling; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IDA:UniProtKB.
DR InterPro; IPR006627; TDU_repeat.
DR InterPro; IPR028184; VGLL4.
DR PANTHER; PTHR17604; PTHR17604; 1.
DR Pfam; PF15245; VGLL4; 1.
DR SMART; SM00711; TDU; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..287
FT /note="Transcription cofactor vestigial-like protein 4"
FT /id="PRO_0000191352"
FT REGION 44..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 58
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14135"
FT MOD_RES 271
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14135"
FT HELIX 204..214
FT /evidence="ECO:0007829|PDB:4LN0"
FT HELIX 215..217
FT /evidence="ECO:0007829|PDB:4LN0"
FT STRAND 227..230
FT /evidence="ECO:0007829|PDB:4LN0"
FT HELIX 234..251
FT /evidence="ECO:0007829|PDB:6SBA"
SQ SEQUENCE 287 AA; 30999 MW; D146298040801D8F CRC64;
MLFMKMDLLN YQYLDKMNNN IGVLCYEGEA SLRGEPRMQT LPVASALSSH RTGPPPISPS
KRKFSMEPGD KDLDCENDHV SKMSRIFSPH LNKTVNGDCR RDPRERSRSP IERAAAPAVS
LHGGHLYASL PSLMEQPLAL TKNSSDTGRS AVERQQNRPS VITCASAGAR NCNLSHCPIA
HSGCSAPGSA SYRRPPSATA TCDPVVEEHF RRSLGKNYKE PEPAPNSVSI TGSVDDHFAK
ALGDTWLQIK AAKDSASSSP ESASRRGQPA SPTAHMVSHS HSPSVVS
