VGLU3_CAEEL
ID VGLU3_CAEEL Reviewed; 544 AA.
AC Q10046;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Potential vesicular glutamate transporter vglu-3;
GN Name=vglu-3; ORFNames=T07A5.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. VGLUT subfamily. {ECO:0000305}.
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DR EMBL; Z48055; CAA88134.1; -; Genomic_DNA.
DR PIR; T24633; T24633.
DR RefSeq; NP_499277.1; NM_066876.3.
DR AlphaFoldDB; Q10046; -.
DR SMR; Q10046; -.
DR BioGRID; 41636; 1.
DR DIP; DIP-25883N; -.
DR STRING; 6239.T07A5.3; -.
DR PaxDb; Q10046; -.
DR EnsemblMetazoa; T07A5.3.1; T07A5.3.1; WBGene00011556.
DR GeneID; 176442; -.
DR KEGG; cel:CELE_T07A5.3; -.
DR UCSC; T07A5.3; c. elegans.
DR CTD; 176442; -.
DR WormBase; T07A5.3; CE01648; WBGene00011556; vglu-3.
DR eggNOG; KOG2532; Eukaryota.
DR GeneTree; ENSGT00970000196433; -.
DR HOGENOM; CLU_001265_5_0_1; -.
DR InParanoid; Q10046; -.
DR OMA; IRNCANA; -.
DR OrthoDB; 497052at2759; -.
DR PhylomeDB; Q10046; -.
DR Reactome; R-CEL-210500; Glutamate Neurotransmitter Release Cycle.
DR Reactome; R-CEL-428643; Organic anion transporters.
DR PRO; PR:Q10046; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00011556; Expressed in adult organism and 1 other tissue.
DR GO; GO:0060076; C:excitatory synapse; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0030285; C:integral component of synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:0005313; F:L-glutamate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005326; F:neurotransmitter transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:anion transport; IBA:GO_Central.
DR GO; GO:0098700; P:neurotransmitter loading into synaptic vesicle; IBA:GO_Central.
DR GO; GO:0050803; P:regulation of synapse structure or activity; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0035249; P:synaptic transmission, glutamatergic; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..544
FT /note="Potential vesicular glutamate transporter vglu-3"
FT /id="PRO_0000220943"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..154
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..219
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..323
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..384
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..416
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 438..450
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 472..544
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 501..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 544 AA; 60543 MW; 4615B3C27D9F86CC CRC64;
MPNGSIRNCA NAVADTVRQT FSRKTWEHKE QLQTITEQKK FFLRKVRWQI AILAHFGFAI
SFGIRSNFGV AKNRMVNNFT DAYGEVHERE FLWTGAEVGM MESSFFYGYA ASQIPAGVLA
AKFAPNKIFM LGILVASFMN ILSAISFNFH PYTDIFVMVV QAVQGLALGV LYPAMHGVWK
FWAPPLERSK LATTAFTGSS VGVMTGLPAS AYLVSHFSWS TPFYVFGVVG IIWSLIWMYV
SSHSPETHGY ISDDEKKQVT EKIGDVAVKN MSLTTLPWRD MMTSSAVWAI IICTFCRSWG
FFLLLGNQLT YMKDVLHIDI KNSGFISIFP QFGMCIVTLA TGQLCDYLRS SGKMSTEAVR
KSVNTFGFTV EAMMLGCLAF VRDPVIAVTC LVIACTGSGS VLSGFNVNHF DIAPRYAPIL
MGIANGLGAV AGVGGMVTNT VTYQNPDGWK WVFLLAMAID IFGVIFFLIF AKGDVLPWAR
EPEKEETFNE FVRRMSIKVR SLSRKTRNRE GDTSYEKMEE DSEMKPCSKK VEARAPAEKS
ESSS
