ID   VGRG2_AERHY             Reviewed;         681 AA.
AC   Q0PZH5;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Type VI secretion system spike protein VgrG2;
GN   Name=vgrG2 {ECO:0000312|EMBL:ABG57133.1};
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SSU;
RX   PubMed=18037263; DOI=10.1016/j.micpath.2007.10.005;
RA   Suarez G., Sierra J.C., Sha J., Wang S., Erova T.E., Fadl A.A., Foltz S.M.,
RA   Horneman A.J., Chopra A.K.;
RT   "Molecular characterization of a functional type VI secretion system from a
RT   clinical isolate of Aeromonas hydrophila.";
RL   Microb. Pathog. 44:344-361(2008).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=SSU;
RX   PubMed=23519162; DOI=10.1099/mic.0.063495-0;
RA   Sha J., Rosenzweig J.A., Kozlova E.V., Wang S., Erova T.E., Kirtley M.L.,
RA   van Lier C.J., Chopra A.K.;
RT   "Evaluation of the roles played by Hcp and VgrG type 6 secretion system
RT   effectors in Aeromonas hydrophila SSU pathogenesis.";
RL   Microbiology 159:1120-1135(2013).
CC   -!- FUNCTION: Part of the type VI secretion system specialized secretion
CC       system, which delivers several virulence factors in both prokaryotic
CC       and eukaryotic cells during infection. Plays an essential role in
CC       bacterial mobility and biofilm formation.
CC       {ECO:0000269|PubMed:23519162}.
CC   -!- DISRUPTION PHENOTYPE: Deletion positively influences motility while it
CC       has a negative effect on biofilm formation.
CC       {ECO:0000269|PubMed:23519162}.
CC   -!- SIMILARITY: Belongs to the VgrG protein family. {ECO:0000305}.
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DR   EMBL; DQ667172; ABG57133.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0PZH5; -.
DR   SMR; Q0PZH5; -.
DR   STRING; 1448139.AI20_13630; -.
DR   Gene3D; 2.40.50.230; -; 1.
DR   InterPro; IPR006531; Gp5/Vgr_OB.
DR   InterPro; IPR017847; T6SS_RhsGE_Vgr_subset.
DR   InterPro; IPR006533; T6SS_Vgr_RhsGE.
DR   InterPro; IPR037026; Vgr_OB-fold_dom_sf.
DR   Pfam; PF04717; Phage_base_V; 1.
DR   TIGRFAMs; TIGR01646; vgr_GE; 1.
DR   TIGRFAMs; TIGR03361; VI_Rhs_Vgr; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..681
FT                   /note="Type VI secretion system spike protein VgrG2"
FT                   /id="PRO_0000448970"
FT   REGION          284..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   681 AA;  75502 MW;  4FF9E7D12E7F567E CRC64;
     MADSTGLQFT VKVGALPENT FVVAEFALDE ALNRPFNLRL ELASAQPDID FGAVLDQPCE
     LLVWYNGELQ RRVCGVVSDF AQGDSGFRRT RYQLMVQPAL WRLSLRQNSR IFQAQKPDEI
     LSILLQEHGI TDYAFALKNE HAKREYCVQY RETGLDFVNR LAAEEGMFYF HEFEVGKHRI
     VFADDSAALT AGPELFFNLG NRSLEQGPYV RQFHYREAVR PSDVELKDYS FKTPAYGLSH
     KKVGAELTHQ RDTYQHFDFP GRYKEDPSGK AFAQHRLDAL RNDAVAGSGK SNSSALQPGQ
     TFSLTEHPND SLNTDWQIVR IQHTGLQSQA LEEEGGSGPT VYHNEFGVVK ASTTWRARIG
     SPEAPHKPMV DGPQIAVVVG PEGEEIYCDE HGRVKLQFPW DRYGSSNDQS SCWVRVSQGW
     AGGQYGMMAI PRIGHEVIVS FLEGDPDQPI VTGRTYHATN RPPYELPANK TRTVLRTETH
     QGEGFNELRF EDQAGKEEIY IHGQKDLNVL IENDAAWHIK HDQHTDIDNE RVTRIKANDH
     LTVEGEKRDQ IKADYSLTVD ASLHQKLGQS LLVEAGSEVH HKAGMKIVME AGAELTLKVG
     GSFVKIDPSG VTLSGGSIKM NSGGSPGSGS GWAGQMPIQP GAVEVVAPPP PMDPARQIAT
     LKSAEPVCEI CEQLARQEGG G