ID   VGRG3_AERHY             Reviewed;         682 AA.
AC   Q0PZF7;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Type VI secretion system spike protein VgrG3;
GN   Name=vgrG3;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SSU;
RX   PubMed=18037263; DOI=10.1016/j.micpath.2007.10.005;
RA   Suarez G., Sierra J.C., Sha J., Wang S., Erova T.E., Fadl A.A., Foltz S.M.,
RA   Horneman A.J., Chopra A.K.;
RT   "Molecular characterization of a functional type VI secretion system from a
RT   clinical isolate of Aeromonas hydrophila.";
RL   Microb. Pathog. 44:344-361(2008).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=SSU;
RX   PubMed=23519162; DOI=10.1099/mic.0.063495-0;
RA   Sha J., Rosenzweig J.A., Kozlova E.V., Wang S., Erova T.E., Kirtley M.L.,
RA   van Lier C.J., Chopra A.K.;
RT   "Evaluation of the roles played by Hcp and VgrG type 6 secretion system
RT   effectors in Aeromonas hydrophila SSU pathogenesis.";
RL   Microbiology 159:1120-1135(2013).
CC   -!- FUNCTION: Part of the type VI secretion system specialized secretion
CC       system, which delivers several virulence factors in both prokaryotic
CC       and eukaryotic cells during infection. Plays an essential role in
CC       bacterial mobility and biofilm formation.
CC       {ECO:0000269|PubMed:23519162}.
CC   -!- DISRUPTION PHENOTYPE: Deletion negatively influences motility and
CC       biofilm formation. {ECO:0000269|PubMed:23519162}.
CC   -!- SIMILARITY: Belongs to the VgrG protein family. {ECO:0000305}.
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DR   EMBL; DQ667172; ABG57151.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0PZF7; -.
DR   SMR; Q0PZF7; -.
DR   STRING; 1448139.AI20_09890; -.
DR   Gene3D; 2.40.50.230; -; 1.
DR   InterPro; IPR006531; Gp5/Vgr_OB.
DR   InterPro; IPR017847; T6SS_RhsGE_Vgr_subset.
DR   InterPro; IPR006533; T6SS_Vgr_RhsGE.
DR   InterPro; IPR037026; Vgr_OB-fold_dom_sf.
DR   Pfam; PF04717; Phage_base_V; 1.
DR   TIGRFAMs; TIGR01646; vgr_GE; 1.
DR   TIGRFAMs; TIGR03361; VI_Rhs_Vgr; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..682
FT                   /note="Type VI secretion system spike protein VgrG3"
FT                   /id="PRO_0000448971"
SQ   SEQUENCE   682 AA;  75760 MW;  195C4B89A1EE756B CRC64;
     MADSTGLQFT VKVGALPEST FVVAEFALDE GLNRPFNLRL ELASRQPDID FGAVLDQPCE
     LLVWYNGELQ RRVCGVVSDM AQGDSGFRRT RYQLLVLPAL WRLSLRQNSR IFQAQKPDEI
     LSILLQEHGI TDYAFALKNE HAKREYCVQY RETDLDFVNR LAAEEGMFYF HEFEAGKHRI
     VFADDAAALT QGPELFFNLG NRSLEQGPYV RQFHYREAVR PSDVELKDYS FKTPAYGLSH
     KKQGADLDHQ RDTYQHFDFP GRYKQGGSGK AFAQHRLDAL RNDAVAGSGK SNCAALQPGQ
     TFSLTEHPNG GLNTDWQVVR IQHTGLQPQA LEEEGGSGPT VYHNEFGVVK ASSTWRARIG
     SPEALHKPMV DGPQIAMVVG PEGEEIYCDE HGRVKLQFPW DRYGSSNDQS SCWVRVSQGW
     AGGQYGMMAI PRIGHEVIVS FLEGDPDQPI VTGRTYHATN RPPYELPANK ARTVLRTETH
     QGEGFNELRF EDQAGQEEIY IHGQKDLNVL IENNAVWHIK HDEHRDIDNE RVTRIKANDH
     LTVEGEKRDQ IKADYSLTVD ASLHQKLGQS LLVEAGQEVH IKVGDKLVLE AGSEITLKGG
     GSFVKVDPSG IKLMGPAIKL NAGGSAGSGS GWGGKAPVVP KGVEVVKAPE LVELVKAIPT
     EKAMEALLKE QGPAQTFFVP SR