ID   VHCD_METVO              Reviewed;         144 AA.
AC   Q00405;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=F420-non-reducing hydrogenase vhc iron-sulfur subunit D;
DE            EC=1.12.99.-;
GN   Name=vhcD;
OS   Methanococcus voltae.
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=2188;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33273 / DSM 1537 / NBRC 100457 / OCM 70 / PS;
RX   PubMed=1603063; DOI=10.1007/bf00587582;
RA   Halboth S., Klein A.;
RT   "Methanococcus voltae harbors four gene clusters potentially encoding two
RT   [NiFe] and two [NiFeSe] hydrogenases, each of the cofactor F420-reducing or
RT   F420-non-reducing types.";
RL   Mol. Gen. Genet. 233:217-224(1992).
RN   [2]
RP   TRANSCRIPTIONAL REGULATION.
RC   STRAIN=ATCC 33273 / DSM 1537 / NBRC 100457 / OCM 70 / PS;
RX   PubMed=8121392; DOI=10.1007/bf00281785;
RA   Berghoefer Y., Agha-Amiri K., Klein A.;
RT   "Selenium is involved in the negative regulation of the expression of
RT   selenium-free [NiFe] hydrogenases in Methanococcus voltae.";
RL   Mol. Gen. Genet. 242:369-373(1994).
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC   -!- SUBUNIT: The F420-non-reducing hydrogenase vhc is composed of three
CC       subunits; VhcA, VhcD and VhcG. {ECO:0000250}.
CC   -!- INDUCTION: By selenium deprivation. {ECO:0000269|PubMed:8121392}.
CC   -!- SIMILARITY: Belongs to the MvhD/VhuD family. {ECO:0000305}.
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DR   EMBL; X61203; CAA43504.1; -; Genomic_DNA.
DR   PIR; B59304; B59304.
DR   AlphaFoldDB; Q00405; -.
DR   SMR; Q00405; -.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR003813; MvhD/FlpD.
DR   Pfam; PF02662; FlpD; 1.
PE   2: Evidence at transcript level;
KW   2Fe-2S; Electron transport; Iron; Iron-sulfur; Metal-binding;
KW   Oxidoreductase; Transport.
FT   CHAIN           1..144
FT                   /note="F420-non-reducing hydrogenase vhc iron-sulfur
FT                   subunit D"
FT                   /id="PRO_0000218277"
SQ   SEQUENCE   144 AA;  16314 MW;  39ED522E9A1D76D1 CRC64;
     MAENWEPKIV GFCCNWCTYG GADTAGVGRM QYPPSIRIIR VMCSGRIEPS FILKAFKEGA
     DGVFIGGCHP GDCHYDAGNY KWQRRVMMLY DMLDELGIEK ERVMHEWISA SEGEKFQIAM
     NDIYDKIKAM GPCTLKENTG KIDE