ID   VHR2_CWPXG              Reviewed;         170 AA.
AC   P87604;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   02-JUN-2021, entry version 48.
DE   RecName: Full=Probable host range protein 2;
GN   ORFNames=C4L;
OS   Cowpox virus (strain GRI-90 / Grishak) (CPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=265871;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8963248;
RA   Safronov P.F., Petrov N.A., Riazankina O.I., Totmenin A.V.,
RA   Shchelkunov S.N., Sandakhchiev L.S.;
RT   "Genes of a circle of hosts for the cowpox virus.";
RL   Dokl. Akad. Nauk 349:829-833(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9568042; DOI=10.1006/viro.1998.9039;
RA   Shchelkunov S.N., Safronov P.F., Totmenin A.V., Petrov N.A.,
RA   Ryazankina O.I., Gutorov V.V., Kotwal G.J.;
RT   "The genomic sequence analysis of the left and right species-specific
RT   terminal region of a cowpox virus strain reveals unique sequences and a
RT   cluster of intact ORFs for immunomodulatory and host range proteins.";
RL   Virology 243:432-460(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10732354;
RA   Riazankina O.I., Tumanova O.I.U., Kolosova I.V., Safronov P.F.,
RA   Kablova G.V., Riazankin I.A., Shchelkunov S.N.;
RT   "Structural-functional organization of Cowpox virus GRI-90 genome. I.
RT   Isolation of clones of DNA fragments of complete Cowpox virus genome.";
RL   Mol. Biol. (Mosk.) 34:160-166(2000).
CC   -!- FUNCTION: Plays a role for multiplication of the virus in different
CC       cell types. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae C7 protein family. {ECO:0000305}.
CC   -!- CAUTION: PubMed:8963248 erroneously termed the gene for this protein
CC       'D4L'. {ECO:0000305}.
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DR   EMBL; X94355; CAD90593.1; -; Genomic_DNA.
DR   SMR; P87604; -.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR004967; Poxvirus_C7/F8A.
DR   Pfam; PF03287; Pox_C7_F8A; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..170
FT                   /note="Probable host range protein 2"
FT                   /id="PRO_0000099393"
FT   REGION          145..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   170 AA;  19935 MW;  8C9B8E2A7D1519BD CRC64;
     MHVFYAVIDN TIDLECLTLH KGVEYGCKLQ LISKNTKTVN IKCITEVYYS DHLLKPLMAY
     VNDKLIQLDR KKLRHKIVYS IDLTLYDEVT NMLVCSNMDP DLIDRYYAKI CLDFDNNVYT
     VKDKNYTNAV IEYPVVCNFR RYSESDSDSD VDDRAELHKR NNDSDSDDYT