VHR2_YEAST
ID VHR2_YEAST Reviewed; 505 AA.
AC P40041; D3DLW9;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Transcription factor VHR2;
DE AltName: Full=VHT1 regulator 2;
GN Name=VHR2; OrderedLocusNames=YER064C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=11342098; DOI=10.1016/s0167-4781(00)00246-3;
RA Kennedy M.A., Bard M.;
RT "Positive and negative regulation of squalene synthase (ERG9), an
RT ergosterol biosynthetic gene, in Saccharomyces cerevisiae.";
RL Biochim. Biophys. Acta 1517:177-189(2001).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP DNA-BINDING, AND POSSIBLE FUNCTION.
RX PubMed=22189060; DOI=10.1186/gb-2011-12-12-r125;
RA Gordan R., Murphy K.F., McCord R.P., Zhu C., Vedenko A., Bulyk M.L.;
RT "Curated collection of yeast transcription factor DNA binding specificity
RT data reveals novel structural and gene regulatory insights.";
RL Genome Biol. 12:RESEARCH0125.1-RESEARCH0125.18(2011).
CC -!- FUNCTION: Transcription factor that regulates ERG9, but seems to have a
CC more global function in transcription. {ECO:0000269|PubMed:11342098}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 1730 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the VHR1 family. {ECO:0000305}.
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DR EMBL; U18813; AAB64600.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07723.1; -; Genomic_DNA.
DR PIR; S50567; S50567.
DR RefSeq; NP_010986.1; NM_001178955.1.
DR AlphaFoldDB; P40041; -.
DR BioGRID; 36806; 53.
DR DIP; DIP-4619N; -.
DR IntAct; P40041; 5.
DR MINT; P40041; -.
DR STRING; 4932.YER064C; -.
DR iPTMnet; P40041; -.
DR MaxQB; P40041; -.
DR PaxDb; P40041; -.
DR PRIDE; P40041; -.
DR EnsemblFungi; YER064C_mRNA; YER064C; YER064C.
DR GeneID; 856793; -.
DR KEGG; sce:YER064C; -.
DR SGD; S000000866; VHR2.
DR VEuPathDB; FungiDB:YER064C; -.
DR eggNOG; ENOG502QVE1; Eukaryota.
DR GeneTree; ENSGT00940000176700; -.
DR HOGENOM; CLU_006698_2_0_1; -.
DR InParanoid; P40041; -.
DR BioCyc; YEAST:G3O-30239-MON; -.
DR PRO; PR:P40041; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P40041; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:SGD.
DR InterPro; IPR007147; TF_Vhr.
DR Pfam; PF04001; Vhr1; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..505
FT /note="Transcription factor VHR2"
FT /id="PRO_0000202632"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 56638 MW; DF7C3CB5506AC763 CRC64;
MIDDTENSKI HLEGSHKTGK YTGYGTTHKI RAQLNFNDEK KWKKFSSRRL ELIDSFGLSQ
HKASEQDDNI RQIATILRSE FEYPDTFSAE FEKLVTAAVQ SVRRNRKRSK KKLLDSKKKI
ARGKVQKIPL SPPSSSNMGS CSASNASSSD EEASVKEEPA EHALPSLNTI TSQKLLPYPN
GRTLPPVPTQ VRSLLKKNAS LLRDPSAPYA HGGDEKLQKF DIEDQPLESE QEYDFIAKSI
IVEIVNNAIP LPEQIQRDKF IRPNLTKKKG CQSKVVISNN LRKLILSKIH NSRTCLEMSK
DERNLDSFAN LETLGKNSLM ASISLVVENS FSHLPSSTKQ YLTERLSSIE FLTILSQRLF
MPATRQLFAD LSQEKIQVRV LNLILGSLVK DYGFDASLAP INEIIYHMTL HQYPLVCSNK
QSNPMRPHST SEVLSAHSST KDASTPGKEE PRVTRSSTSA DSTIITLPSI EVPNTYDDDR
LKMLSAISLQ IENSTFSKPF STISK
