VHT1_SCHPO
ID VHT1_SCHPO Reviewed; 568 AA.
AC O13880;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Vitamin H transporter 1;
DE AltName: Full=H(+)/biotin symporter vht1;
GN Name=vht1; ORFNames=SPAC1B3.16c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=12557275; DOI=10.1002/yea.959;
RA Stolz J.;
RT "Isolation and characterization of the plasma membrane biotin transporter
RT from Schizosaccharomyces pombe.";
RL Yeast 20:221-231(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Involved in uptake of biotin and desthiobiotin with the
CC concomitant entry of protons. {ECO:0000269|PubMed:12557275}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Allantoate
CC permease family. {ECO:0000305}.
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DR EMBL; AY179181; AAO22560.1; -; mRNA.
DR EMBL; CU329670; CAB11242.1; -; Genomic_DNA.
DR PIR; T38035; T38035.
DR RefSeq; NP_594801.1; NM_001020229.2.
DR AlphaFoldDB; O13880; -.
DR BioGRID; 278976; 68.
DR STRING; 4896.SPAC1B3.16c.1; -.
DR TCDB; 2.A.1.14.19; the major facilitator superfamily (mfs).
DR iPTMnet; O13880; -.
DR MaxQB; O13880; -.
DR PaxDb; O13880; -.
DR PRIDE; O13880; -.
DR EnsemblFungi; SPAC1B3.16c.1; SPAC1B3.16c.1:pep; SPAC1B3.16c.
DR GeneID; 2542518; -.
DR KEGG; spo:SPAC1B3.16c; -.
DR PomBase; SPAC1B3.16c; vht1.
DR VEuPathDB; FungiDB:SPAC1B3.16c; -.
DR eggNOG; KOG2533; Eukaryota.
DR HOGENOM; CLU_001265_0_0_1; -.
DR InParanoid; O13880; -.
DR PhylomeDB; O13880; -.
DR PRO; PR:O13880; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IMP:PomBase.
DR GO; GO:0031224; C:intrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0015225; F:biotin transmembrane transporter activity; IMP:PomBase.
DR GO; GO:1901604; F:dethiobiotin transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0015295; F:solute:proton symporter activity; IMP:PomBase.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1905135; P:biotin import across plasma membrane; IMP:PomBase.
DR GO; GO:1905136; P:dethiobiotin import across plasma membrane; IMP:PomBase.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Biotin; Membrane; Reference proteome; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..568
FT /note="Vitamin H transporter 1"
FT /id="PRO_0000121371"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 547..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 62822 MW; CD9471C5BE175E41 CRC64;
MASEWPETSR ASSVEENPKL NIPEIVESVS DSKPSLKNQF STTVIDSSDL NVFNDGAETT
VKEQEFTSSE LRRLQKLRLK MDLRIIPCLW ILYFLSCCLR FTVSLSFTMN TAQGHSLIQT
LSGYSAHYLA LGLALFYVGY IIFEVPSNLM MAFIEPRIWV SRIQLTIGVV GACHAVLGTK
HGNAQSYVAL RFFLGVAESG LWPGLAYYMS RWYRGKHLGK RIGWYYTAAQ IAAAAVSLVS
AGFQKMDGAR GLYGYQWMFL IWGVVAIAQA LSIPWWLPAV ASKEHRKSLS SFIPLPKWMK
TLSPQRIGFL TPADKSLHSR YIAEMNVGKR WQWSDLLKSC LDLRVWPFIL MYFGIVGVGN
GIFNYCTLII EEINPSFSGI DISLLNAPIW LADALGIVTV MPLYDRFHKK FSFFTGSCLI
IIAGLAVANY APRAWSRYGG LLMIGFGLGP TVPICMAWCS ASMAKTYGDV GVASSLALVT
GLGNLGSVVT TYALYSGWPG DPTFRKSNDV CIALIGVSII ACGIEFLLDK TGFGQFNASF
NNHDHEVEDE QEMTDIKPAL PSSQQADA
