ID   VIB1_NEUCR              Reviewed;         670 AA.
AC   Q9C2N1; Q1K7Y1; V5ILE2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Transcription factor vib-1;
DE   AltName: Full=Vegetative incompatibility blocked protein 1;
GN   Name=vib-1; ORFNames=17E5.170, NCU03725;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=12242225; DOI=10.1093/genetics/162.1.89;
RA   Xiang Q., Glass N.L.;
RT   "Identification of vib-1, a locus involved in vegetative incompatibility
RT   mediated by het-c in Neurospora crassa.";
RL   Genetics 162:89-101(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [4]
RP   FUNCTION.
RX   PubMed=15531211; DOI=10.1016/j.fgb.2004.07.006;
RA   Xiang Q., Glass N.L.;
RT   "The control of mating type heterokaryon incompatibility by vib-1, a locus
RT   involved in het-c heterokaryon incompatibility in Neurospora crassa.";
RL   Fungal Genet. Biol. 41:1063-1076(2004).
RN   [5]
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=17012538; DOI=10.1128/ec.00253-06;
RA   Dementhon K., Iyer G., Glass N.L.;
RT   "VIB-1 is required for expression of genes necessary for programmed cell
RT   death in Neurospora crassa.";
RL   Eukaryot. Cell 5:2161-2173(2006).
CC   -!- FUNCTION: Transcription factor that acts as a positive regulator of
CC       nonrepressible acid phosphatase activity. Is a major regulator of
CC       responses to nitrogen and carbon starvation and is essential for the
CC       expression of genes involved in vegetative incompatibility (like pin-c,
CC       het-6, and tol). Vegetative incompatibility is a non-self-recognition
CC       system ubiquitous in filamentous fungi which results in programmed cell
CC       death. {ECO:0000269|PubMed:12242225, ECO:0000269|PubMed:15531211,
CC       ECO:0000269|PubMed:17012538}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17012538}. Cytoplasm
CC       {ECO:0000269|PubMed:17012538}. Note=Localized in nuclei of all
CC       vegetative hyphae and cytoplasmically localized in conidiophores and
CC       immature conidia.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ESA42442.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL513467; CAC28843.1; -; Genomic_DNA.
DR   EMBL; BK000540; DAA00072.1; -; Genomic_DNA.
DR   EMBL; CM002240; ESA42442.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_011394570.1; XM_011396268.1.
DR   AlphaFoldDB; Q9C2N1; -.
DR   STRING; 5141.EFNCRP00000003366; -.
DR   EnsemblFungi; ESA42442; ESA42442; NCU03725.
DR   GeneID; 3877601; -.
DR   KEGG; ncr:NCU03725; -.
DR   HOGENOM; CLU_019835_1_0_1; -.
DR   InParanoid; Q9C2N1; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000228; C:nuclear chromosome; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.60.40.1390; -; 1.
DR   InterPro; IPR024061; NDT80_DNA-bd_dom.
DR   InterPro; IPR037141; NDT80_DNA-bd_dom_sf.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   Pfam; PF05224; NDT80_PhoG; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS51517; NDT80; 1.
PE   4: Predicted;
KW   Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..670
FT                   /note="Transcription factor vib-1"
FT                   /id="PRO_0000371412"
FT   DNA_BIND        106..341
FT                   /note="NDT80"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00850"
FT   REGION          394..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          496..670
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..438
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        503..544
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..570
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        581..595
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..650
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   670 AA;  72972 MW;  FB16A2D4E19A1ED0 CRC64;
     MAELRAETQH GGIWPNYGNP VQMNTGRYNT QESSVPVGSA ASSHLVRPRS RQHTMDYHNA
     PYHHGRPAQE DGDGYERYPH PSLMNIPSIT TGMKRSYSQV DQTPYTEMVQ DLRDDYKPAM
     NHDQKLLSFK KVGDKHTIVD HKGRIHEIEI EAQLHGMFFL SEFPSPGDGN VLNAELTCYR
     RNLFQISGNI CFPQIPLSVM LETGETSQIK NMEVTISAIE SVDGHPVRLI VIPWKTPPPN
     SPEVNQAPDQ EPPSLPLIPW SEEEEDNGGD HYAIYPIGWR RLQFRIATAN NGRRKELQQH
     FVLHLKLHGT LANGTKLVLS ELTTAPIVVR GRSPRNFQAR KEIPLLGSSA GSRGQTLVET
     GHSIVAQAVA LNKPPYDSRP RVSSMDLPRT AFTFTSAKQM PQSPMQMRSN SYPTSWNPSS
     QVSMPHNPGS TSYPTTSMAG PEPYPKMPLS GAPSYTAEPQ EMPIQQTSMP SMQLSMVAQD
     QQPSAPIRTQ YATYASAPPP HLSLPSTADS SLNVPRYVDS NPRPSKSPRH GSHGSLTNET
     ASGEYRYGPP SYLGNSSSDI SPQSQHHPPT SGAGAGGASS GAYGTPSQEG GASAPASAPT
     SAAPPRDYFP PSQSWTSTAG EGQTSSYTNG GDRSYSFPTG VKTEPHSQPS HSGAPVPGVY
     GNNHYAWNAT