ID   VIBC_VIBCH              Reviewed;         395 AA.
AC   O07898; Q9JQ09;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Vibriobactin-specific isochorismate synthase;
DE            EC=5.4.4.2;
DE   AltName: Full=Isochorismate mutase;
GN   Name=vibC; OrderedLocusNames=VC_0773;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=El Tor Lou15;
RX   PubMed=9371453; DOI=10.1128/jb.179.22.7055-7062.1997;
RA   Wyckoff E.E., Stoebner J.A., Reed K.E., Payne S.M.;
RT   "Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of
RT   genes required for early steps in siderophore biosynthesis.";
RL   J. Bacteriol. 179:7055-7062(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC         ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC   -!- PATHWAY: Siderophore biosynthesis; vibriobactin biosynthesis.
CC   -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; U52150; AAC45925.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF93938.1; -; Genomic_DNA.
DR   PIR; A82283; A82283.
DR   RefSeq; NP_230422.1; NC_002505.1.
DR   RefSeq; WP_000245175.1; NZ_LT906614.1.
DR   AlphaFoldDB; O07898; -.
DR   SMR; O07898; -.
DR   STRING; 243277.VC_0773; -.
DR   DNASU; 2615316; -.
DR   EnsemblBacteria; AAF93938; AAF93938; VC_0773.
DR   GeneID; 57739483; -.
DR   KEGG; vch:VC_0773; -.
DR   PATRIC; fig|243277.26.peg.737; -.
DR   eggNOG; COG1169; Bacteria.
DR   HOGENOM; CLU_006493_8_6_6; -.
DR   OMA; TMWHLSS; -.
DR   BioCyc; MetaCyc:VC0773-MON; -.
DR   BioCyc; VCHO:VC0773-MON; -.
DR   UniPathway; UPA00022; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0008909; F:isochorismate synthase activity; IBA:GO_Central.
DR   GO; GO:0009697; P:salicylic acid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0019537; P:vibriobactin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.120.10; -; 1.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR015890; Chorismate_C.
DR   InterPro; IPR004561; IsoChor_synthase.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   SUPFAM; SSF56322; SSF56322; 1.
DR   TIGRFAMs; TIGR00543; isochor_syn; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..395
FT                   /note="Vibriobactin-specific isochorismate synthase"
FT                   /id="PRO_0000154152"
SQ   SEQUENCE   395 AA;  43594 MW;  2FFAF87DD948C78B CRC64;
     MVMKREVVGY TTMSEHLIDT QLTRSPFFFA SANQSMLGCG VAHAFQQAIP FAELANQAKQ
     LLQQAKRDEC DNPLLFGIVP FDPKTPTRFM IPRTLYVSSS PRLNRPAHLT RQVAKLISSP
     SGEQYKQGVS HLLNMFHHSG LSKVVLSRAI EIATEQEIAL PTLLRSLLAI NHHGYTFAAS
     LDEQRKLIGA SPELLVAKRG NYLISNPLAG SRPRSQDAQE NAQRRASLLN TAKDLHEHGL
     VVEEVERIMS RYCRNLYTPM VPSVIETETM LHLSTLLEGQ VSDPEVCALQ VAADLHPTPA
     VCGFPRESAY QAIRELEEFD RGYFTGMVGW CDARGNGEWV VTIRCAEVGS HQMKLFAGAG
     IVDESLPQSE LEETGAKMKT ILAAAGIELN DVLTA