ID   VIE1_MUHVS              Reviewed;         595 AA.
AC   P11210;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Immediate-early protein 1;
DE            Short=IE1;
DE   AltName: Full=Immediate-early phosphoprotein PP89;
GN   Name=IE1;
OS   Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Muromegalovirus.
OX   NCBI_TaxID=10367;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate ATCC VR-1399;
RX   PubMed=3033321; DOI=10.1128/jvi.61.6.1901-1908.1987;
RA   Keil G.M., Ebeling-Keil A., Koszinowski U.H.;
RT   "Sequence and structural organization of murine cytomegalovirus immediate-
RT   early gene 1.";
RL   J. Virol. 61:1901-1908(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8971012; DOI=10.1128/jvi.70.12.8833-8849.1996;
RA   Rawlinson W.D., Farrell H.E., Barrell B.G.;
RT   "Analysis of the complete DNA sequence of murine cytomegalovirus.";
RL   J. Virol. 70:8833-8849(1996).
CC   -!- FUNCTION: The IE1 protein has some additive effect on the trans-
CC       activating properties of the IE3 protein.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=IE1;
CC         IsoId=P11210-1; Sequence=Displayed;
CC       Name=IE3;
CC         IsoId=P11210-2; Sequence=Not described;
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DR   EMBL; M11788; AAA45981.1; -; Genomic_DNA.
DR   EMBL; U68299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A27823; EDBEMC.
DR   SMR; P11210; -.
DR   PRIDE; P11210; -.
DR   Proteomes; UP000008774; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Alternative splicing; Early protein; Host nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..595
FT                   /note="Immediate-early protein 1"
FT                   /id="PRO_0000115357"
FT   REGION          384..595
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..441
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..498
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..521
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        544..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   595 AA;  66709 MW;  F97FFC7AA1A9FE63 CRC64;
     MEPAAPSCNM IMIADQASVN AHGRHLDENR VYPSDKVPAH VANKILESGT ETVRCDLTLE
     DMLGDYEYDD PTEEEKILMD RIADHVGNDN SDMAIKHAAV RSVLLSCKIA HLMIKQNYQS
     AINSATNILC QLANDIFERI ERQRKMIYGC FRSEFDNVQL GRLMYDMYPH FMPTNLGPSE
     KRVWMSYVGE AIVAATNIDH ALDERAAWAK TDCSLPGEFK PELCVLVGAI RRLHDPPCYT
     KPFLDAKSQL AVWQQMKAIE SESVSTHVVV VEALKLRENL AKAVQETIAY ERHQYHRVCQ
     MMCNNMKDHL ETTCMLARGR TLATLADLRS TRYNLALFLL SEMHIFDSFT MPRIRGAMKQ
     ARCMSYVERT ISLAKFRELA DRVHNRSAPS PQGVIEEQQQ AGEEEQQQQQ EIEYDPEMPP
     LEREEEQEDE QVEEEPPADE EEGGAVGGVT QEEPAGEATE EAEEDESQPG PSDNQVVPES
     SETPTPAEDE ETQSADEGES QELEGSQQLI LSRPAAPLTD SETDSDSEDD DEVTRIPVGF
     SLMTSPVLQP TTRSATAAAS SGTAPRPALK RQYAMVHTRS KSSENQQQPK KKSKK