ID   VIE2_MUHVS              Reviewed;         391 AA.
AC   P24909;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   02-DEC-2020, entry version 59.
DE   RecName: Full=Immediate-early protein 2;
DE            Short=IE2;
GN   Name=IE2;
OS   Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Muromegalovirus.
OX   NCBI_TaxID=10367;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1847480; DOI=10.1128/jvi.65.3.1638-1643.1991;
RA   Messerle M., Keil G.M., Koszinowski U.H.;
RT   "Structure and expression of murine cytomegalovirus immediate-early gene
RT   2.";
RL   J. Virol. 65:1638-1643(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8971012; DOI=10.1128/jvi.70.12.8833-8849.1996;
RA   Rawlinson W.D., Farrell H.E., Barrell B.G.;
RT   "Analysis of the complete DNA sequence of murine cytomegalovirus.";
RL   J. Virol. 70:8833-8849(1996).
CC   -!- FUNCTION: Involved in the reactivation of latent MCMV in spleen cells.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
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DR   EMBL; L06816; AAA74503.1; -; Genomic_DNA.
DR   EMBL; M64230; AAA45949.1; -; Genomic_DNA.
DR   EMBL; U68299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A38470; EDBEMT.
DR   Proteomes; UP000008774; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 1.
PE   3: Inferred from homology;
KW   Early protein; G0/G1 host cell cycle checkpoint dysregulation by virus;
KW   Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Modulation of host cell cycle by virus; Reference proteome.
FT   CHAIN           1..391
FT                   /note="Immediate-early protein 2"
FT                   /id="PRO_0000115354"
SQ   SEQUENCE   391 AA;  43801 MW;  81FA576EB9B16CCB CRC64;
     MERVRGASSS DSVATLHGDH NYHCMATFKL DCTSARTRGV VSILEHRDPA TVDDIFMQRV
     CHDINDVLRP VECLTSFPEY RRTLRVAVEA ATELHGVSAL SGQLTKFLED HDGAMLPLAW
     PPNRYLRLTS GRKLGYLDVA EKLRKEYPMC NGPLEVLGVI LGPGQSLYSD QHPVLLMGLT
     GTIFLHARGR PVWSPDYDPE RDADRLFLAA ESLQSFGREG LCRCDNVYTE DGGAPYATPE
     DPVLKNIVFT PHLGGKALHQ QICKIKGHTW YLNGCPGMLK DRVFVATPDI PPFVRHVNLE
     LFGHRFLPIG RVTRSPEDPE CEMFIMVDAG GAIYGHMLDS GKVRRLADNF DQFMRMGTRR
     VISISRWLRE VVSTPSTRRP RLGPRTTGSF S