ID   VIE3_HCMVT              Reviewed;         280 AA.
AC   P06434;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   02-JUN-2021, entry version 51.
DE   RecName: Full=30 kDa immediate-early protein 2;
DE            Short=IE2;
GN   Name=UL122;
OS   Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10363;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2999423; DOI=10.1128/jvi.56.3.665-675.1985;
RA   Stenberg R.M., Witte P.R., Stinski M.F.;
RT   "Multiple spliced and unspliced transcripts from human cytomegalovirus
RT   immediate-early region 2 and evidence for a common initiation site within
RT   immediate-early region 1.";
RL   J. Virol. 56:665-675(1985).
CC   -!- FUNCTION: Activates the E1.7 promoter. This activation is augmented by
CC       the IE1 protein. It down-regulates the transcription of genes under the
CC       control of the major IE promoter.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=At least 2 isoforms are produced.;
CC       Name=1;
CC         IsoId=P06434-1; Sequence=Displayed;
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DR   EMBL; M11298; AAA45952.1; -; Genomic_DNA.
DR   PIR; A03725; EDBE3T.
DR   DrugBank; DB06759; Fomivirsen.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005028; Herpes_IE2_3.
DR   Pfam; PF03361; Herpes_IE2_3; 1.
PE   4: Predicted;
KW   Alternative splicing; Early protein.
FT   CHAIN           1..280
FT                   /note="30 kDa immediate-early protein 2"
FT                   /id="PRO_0000115353"
FT   REGION          36..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  30329 MW;  DFC9F3427ADFE36A CRC64;
     MLPLIKQEDI KPEPDFTIQY RNKIIDTAGC IVISDSEEEQ GEEVETRGAT ASSPSTGSGT
     PRVTSPTHPL SQMNHPPLPD PLGRPDEDSS SSSSSCSSAS DSESESEEMK CSSGGGASVT
     SSHHGRGGFG GAASSSLLSC GHQSSGGAST GPRKKKSKRI SELDNEKVRN IMKDKNTPFC
     TPNVQTRRGR VKIDEVSRMF RNTNRSLEYK NLPFTIPSMH QVLDEAIKAC KTMQVNNKGI
     QIIYTRNHEV KSEVDAVRCR LGTMCTWPSP LPSSWSTPCP