VIGLN_PONAB
ID VIGLN_PONAB Reviewed; 1268 AA.
AC Q5R439;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Vigilin;
DE AltName: Full=High density lipoprotein-binding protein;
DE Short=HDL-binding protein;
GN Name=HDLBP;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Appears to play a role in cell sterol metabolism. It may
CC function to protect cells from over-accumulation of cholesterol (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR EMBL; CR861421; CAH93477.1; -; mRNA.
DR AlphaFoldDB; Q5R439; -.
DR SMR; Q5R439; -.
DR STRING; 9601.ENSPPYP00000014936; -.
DR eggNOG; KOG2208; Eukaryota.
DR InParanoid; Q5R439; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1370.10; -; 14.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR Pfam; PF00013; KH_1; 14.
DR SMART; SM00322; KH; 14.
DR SUPFAM; SSF54791; SSF54791; 12.
DR PROSITE; PS50084; KH_TYPE_1; 14.
PE 2: Evidence at transcript level;
KW Acetylation; Cholesterol metabolism; Cytoplasm; HDL; Lipid metabolism;
KW Lipid transport; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW RNA-binding; Steroid metabolism; Sterol metabolism; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q00341"
FT CHAIN 2..1268
FT /note="Vigilin"
FT /id="PRO_0000269566"
FT DOMAIN 158..229
FT /note="KH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 230..302
FT /note="KH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 303..371
FT /note="KH 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 372..442
FT /note="KH 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 443..514
FT /note="KH 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 515..588
FT /note="KH 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 589..660
FT /note="KH 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 661..734
FT /note="KH 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 735..807
FT /note="KH 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 808..880
FT /note="KH 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 881..979
FT /note="KH 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 980..1059
FT /note="KH 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 1060..1134
FT /note="KH 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 1135..1209
FT /note="KH 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT REGION 910..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q00341"
FT MOD_RES 8
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q00341"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00341"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00341"
FT MOD_RES 35
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Z1A6"
FT MOD_RES 295
FT /note="Phosphothreonine"
FT /evidence="ECO:0000255"
FT MOD_RES 296
FT /note="Phosphothreonine"
FT /evidence="ECO:0000255"
FT MOD_RES 317
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00341"
FT MOD_RES 437
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q00341"
FT MOD_RES 645
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Z1A6"
FT MOD_RES 991
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8VDJ3"
FT MOD_RES 1247
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00341"
FT MOD_RES 1252
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00341"
SQ SEQUENCE 1268 AA; 141302 MW; 99FA3284EE40B5C4 CRC64;
MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEESDPPTY KDAFPPLPEK AACLESAQEP
AGAWGNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ AKICLEIMQR TGAHLELSLA
KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ ASATVAIPKE HHRFVIGKNG EKLQDLELKT
ATKIQIPRPD DPSNQIKITG TKEGIEKARH EVLLISAEQD ERAVERLEVE KAFHPFIAGP
YNRLVGEIMQ ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL GQALTEVYAK
ANSFTVSSVA APSWLHRFII GKKGQNLAKI TQQMPKVHIE FTEGEDKITL EGPTEDVSVT
QEHIEGMVKD LINRMDYVEI NIDHKFHRHL IGKSGANINR IKDQYKVSVR IPPDSEKSNL
IRIEGDPQGV QQAKRELLEL ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV
IINFPDPAQK SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL ANIAEVEVSI
PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV VIRGPSSDVE KAKKQLLHLA
EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI RKVRDSTGAR VIFPAAEDKD QDLITIIGKE
DAVREAQKEL EALIQNLDNV VEDSMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS
GTQSDKVTLK GAKGCVEAAK KRIQEIIEDL EAQVTLECAI PQKFHRSVMG PKGSRIQQIT
RDFSVQIKFP DREENPVHST EPAVQENGDE AGEGREAKDS DPGSPRRCDI IIISGRKEKC
EAAKEALEAL VPVTVEVEVP FDLHRYVIGQ KGSGIRKMMD EFEVNIHVPA PELQSDIIAI
TGLAANLDRA KAGLLERVKE LQAEQEDRAL RSFKLSVTVD PKYHPKIIGR KGAVITQIRL
EHDVNIQFPD KGDGNQPQDQ ITITGYEKNT EAARDAILRI VGELEQMVSE DVPLDHRVHA
RIIGARGKAI RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD
VVDSEALQVY MKPPVHEEAK APSRGFVVRD APWAASSSEK APDMSSSEEF PSFGAQVAPK
TLPWGPKR
